Abnormal P300 in people with high risk of developing psychosis
Bramon, Elvira, Shaikh, Madiha, Broome, Matthew R., Lappin, Julia, Bergé, Daniel, Day, Fern, Woolley, J. B. (James B.), Tabraham, Paul, Madre, Mercè, Johns, Louise C., Valmaggia, Lucia, Pérez, Victor, Sham, Pak, Murray, Robin, MD, M Phil, MRCP, MRC Psych and McGuire, Philip. (2008) Abnormal P300 in people with high risk of developing psychosis. Neuroimage, Vol.41 (No.2). pp. 553-560. ISSN 1053-8119
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Official URL: http://dx.doi.org/10.1016/j.neuroimage.2007.12.038...
Individuals with an “at-risk mental state” (or “prodromal” symptoms) have a 20–40% chance of developing psychosis; however it is difficult to predict which of them will become ill on the basis of their clinical symptoms alone. We examined whether neurophysiological markers could help to identify those who are particularly vulnerable.
35 cases meeting PACE criteria for the at-risk mental state (ARMS) and 57 controls performed an auditory oddball task whilst their electroencephalogram was recorded. The latency and amplitude of the P300 and N100 waves were compared between groups using linear regression.
The P300 amplitude was significantly reduced in the ARMS group [8.6 ± 6.4 microvolt] compared to controls [12.7 ± 5.8 microvolt] (p < 0.01). There were no group differences in P300 latency or in the amplitude and latency of the N100. Of the at-risk subjects that were followed up, seven (21%) developed psychosis.
Reduction in the amplitude of the P300 is associated with an increased vulnerability to psychosis. Neurophysiological and other biological markers may be of use to predict clinical outcomes in populations at high risk.
|Item Type:||Journal Article|
|Subjects:||R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
B Philosophy. Psychology. Religion > BF Psychology
|Divisions:||Faculty of Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing
Faculty of Medicine > Warwick Medical School
|Library of Congress Subject Headings (LCSH):||Psychoses, Neuropsychology|
|Journal or Publication Title:||Neuroimage|
|Official Date:||4 January 2008|
|Page Range:||pp. 553-560|
|Access rights to Published version:||Open Access|
Version accepted by publisher (post-print, after peer review, before copy-editing)
Addington, J., Cadenhead, K.S., Cannon, T.D., Cornblatt, B., McGlashan, T.H., Perkins, D.O., Seidman, L.J.,
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