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Epidemiology and risk factors for bipolar disorder
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Rowland, Tobias and Marwaha, Steven (2018) Epidemiology and risk factors for bipolar disorder. Therapeutic Advances in Psychopharmacology, 8 (9). pp. 251-269. doi:10.1177/2045125318769235 ISSN 2045-1253 .
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Official URL: https://doi.org/10.1177/2045125318769235
Abstract
Bipolar disorder is a multifactorial illness with uncertain aetiology. Knowledge of potential risk factors enables clinicians to identify patients who are more likely to develop bipolar disorder, which directs further investigation, follow up and caution when prescribing. Ideally, identifying directly causative factors for bipolar disorder would enable intervention on an individual or population level to prevent the development of the illness, and improve outcomes through earlier treatment. This article reviews the epidemiology of bipolar disorder, along with putative demographic, genetic and environmental risk factors, while assessing the strength of these associations and to what extent they might be said to be ‘causative’. While numerous genetic and environmental risk factors have been identified, the attributable risk of individual factors is often small, and most are not specific to bipolar disorder but are associated with several mental illnesses. Therefore, while some genetic and environmental factors have strong evidence supporting their association with bipolar disorder, fewer have sufficient evidence to establish causality. There is increasing interest in the role of specific gene–environment interactions, as well as the mechanisms by which risk factors interact to lead to bipolar disorder.
| Item Type: | Journal Article | ||||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Mental Health and Wellbeing Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Therapeutic Advances in Psychopharmacology | ||||||||
| Publisher: | Sage Publications Ltd. | ||||||||
| ISSN: | 2045-1253 | ||||||||
| Official Date: | 1 September 2018 | ||||||||
| Dates: |
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| Volume: | 8 | ||||||||
| Number: | 9 | ||||||||
| Page Range: | pp. 251-269 | ||||||||
| DOI: | 10.1177/2045125318769235 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||||
| Date of first compliant deposit: | 19 March 2018 | ||||||||
| Date of first compliant Open Access: | 27 April 2018 | ||||||||
| Related URLs: |
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