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Modelling and estimation of health-related quality of life after hip fracture
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Parsons, Nicholas R., Griffin, Xavier L., Achten, Juul, Chesser, T. J., Lamb, S. E. (Sallie E.) and Costa, Matthew L. (2018) Modelling and estimation of health-related quality of life after hip fracture. Bone & Joint Research, 7 (1). pp. 1-5. doi:10.1302/2046-3758.71.BJR-2017-0199
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WRAP-modelling-estimation-health-related-quality-life-hip-fracture-Parsons-2017.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons: Attribution-Noncommercial 4.0. Download (863Kb) | Preview |
Official URL: http://dx.doi.org/10.1302/2046-3758.71.BJR-2017-01...
Abstract
Objectives:
This study investigates the reporting of health-related quality of life (HRQoL) in patients following hip fracture. We compare the relative merits and make recommendations for the use for two methods of measuring HRQoL; (i) including patients who died during follow-up and (ii) including survivors only.
Methods:
The World Hip Trauma Evaluation has previously reported changes in HRQoL using EuroQol-5D for patients with hip fractures. We performed additional analysis to investigate the effect of including or excluding those patients who died during the first four months of the follow-up period.
Results:
The dataset included 503 patients, 25 of whom died between 30 days and four months of injury. There was a statistically significant difference in 30-day HRQoL between those alive (mean 0.331 and standard deviation (sd) 0.360) and those dead (mean 0.156 and sd 0.421) by four months (independent-samples t-test; p 0.022). The estimated difference of 0.175 in HRQoL (95% confidence interval 0.025 to 0.325) was also highly clinically significant.
Conclusion:
When reporting HRQoL for patients after a hip fracture, excluding patients who die during follow-up leads to an overestimate of the effects of the intervention or treatment pathway. We would recommend that death-adjusted estimates should be used routinely when reporting HRQoL in this population.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Subjects: | R Medicine > RD Surgery | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Pelvic bones -- Fractures -- Rehabilitation | ||||||
| Journal or Publication Title: | Bone & Joint Research | ||||||
| Publisher: | British Editorial Society of Bone and Joint Surgery | ||||||
| ISSN: | 2046-3758 | ||||||
| Official Date: | 1 January 2018 | ||||||
| Dates: |
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| Volume: | 7 | ||||||
| Number: | 1 | ||||||
| Page Range: | pp. 1-5 | ||||||
| DOI: | 10.1302/2046-3758.71.BJR-2017-0199 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access |
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