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Iron core mineralisation in prokaryotic ferritins
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Le Brun, Nick E., Crow, Allister, Murphy, Michael E.P., Mauk, A. Grant and Moore, Geoffrey R. (2010) Iron core mineralisation in prokaryotic ferritins. Biochimica et Biophysica Acta (BBA) - General Subjects, 1800 (8). pp. 732-744. doi:10.1016/j.bbagen.2010.04.002 ISSN 0304-4165.
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Official URL: http://dx.doi.org/10.1016/j.bbagen.2010.04.002
Abstract
Background:
To satisfy their requirement for iron while at the same time countering the toxicity of this highly reactive metal ion, prokaryotes have evolved proteins belonging to two distinct sub-families of the ferritin family: the bacterioferritins (BFRs) and the bacterial ferritins (Ftns). Recently, Ftn homologues have also been identified and characterised in archaeon species. All of these prokaryotic ferritins function by solubilising and storing large amounts of iron in the form of a safe but bio-available mineral.
Scope of review:
The mechanism(s) by which the iron mineral is formed by these proteins is the subject of much current interest. Here we review the available information on these proteins, with particular emphasis on significant advances resulting from recent structural, spectroscopic and kinetic studies.
Major conclusions:
Current understanding indicates that at least two distinct mechanisms are in operation in prokaryotic ferritins. In one, the ferroxidase centre acts as a true catalytic centre in driving Fe2+ oxidation in the cavity; in the other, the centre acts as a gated iron pore by oxidising Fe2+ and transferring the resulting Fe3+ into the central cavity.
General significance:
The prokaryotic ferritins exhibit a wide variation in mechanisms of iron core mineralisation. The basis of these differences lies, at least in part, in structural differences at and around the catalytic centre. However, it appears that more subtle differences must also be important in controlling the iron chemistry of these remarkable proteins.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
| Journal or Publication Title: | Biochimica et Biophysica Acta (BBA) - General Subjects | ||||||
| Publisher: | Elsevier Science BV | ||||||
| ISSN: | 0304-4165 | ||||||
| Official Date: | August 2010 | ||||||
| Dates: |
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| Volume: | 1800 | ||||||
| Number: | 8 | ||||||
| Page Range: | pp. 732-744 | ||||||
| DOI: | 10.1016/j.bbagen.2010.04.002 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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