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Association of Vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects
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Al-Daghri, Nasser, Rahman, Shakilur, Sabico, Shaun, Yakout, Sobhy, Wani, Kaiser, Al-Attas, Omar, Saravanan, Ponnusamy, Tripathi, Gyanendra, McTernan, P. G. and Alokail, Majed (2016) Association of Vitamin B12 with pro-inflammatory cytokines and biochemical markers related to cardiometabolic risk in Saudi subjects. Nutrients, 8 (9). 460. doi:10.3390/nu8090460 ISSN 2072-6643.
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Official URL: https://doi.org/10.3390/nu8090460
Abstract
Background
This study aimed to examine the relationship between changes in systemic vitamin B12 concentrations with pro-inflammatory cytokines, anthropometric factors and biochemical markers of cardiometabolic risk in a Saudi population.
Methods
A total of 364 subjects (224 children, age: 12.99 ± 2.73 (mean ± SD) years; BMI: 20.07 ± 4.92 kg/m2 and 140 adults, age: 41.87 ± 8.82 years; BMI: 31.65 ± 5.77 kg/m2) were studied. Fasting blood, anthropometric and biochemical data were collected. Serum cytokines were quantified using multiplex assay kits and B12 concentrations were measured using immunoassay analyzer. Results: Vitamin B12 was negatively associated with TNF-α (r = −0.14, p < 0.05), insulin (r = −0.230, p < 0.01) and HOMA-IR (r = −0.252, p < 0.01) in all subjects. In children, vitamin B12 was negatively associated with serum resistin (r = −0.160, p < 0.01), insulin (r = −0.248, p < 0.01), HOMA-IR (r = −0.261, p < 0.01). In adults, vitamin B12 was negatively associated with TNF-α (r = −0.242, p < 0.01) while positively associated with resistin (r = 0.248, p < 0.01). Serum resistin was the most significant predictor for circulating vitamin B12 in all subjects (r2 = −0.17, p < 0.05) and in children (r2 = −0.167, p < 0.01) while HDL-cholesterol was the predictor of B12 in adults (r2 = −0.78, p < 0.05).
Conclusions
Serum vitamin B12 concentrations were associated with pro-inflammatory cytokines and biochemical markers of cardiometabolic risks in adults. Maintaining adequate vitamin B12 concentrations may lower inflammation-induced cardiometabolic risk in the Saudi adult population.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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SWORD Depositor: | Library Publications Router | ||||||
Library of Congress Subject Headings (LCSH): | Vitamin B12 deficiency, Diabetes -- Prevention -- Saudi Arabia, Cerebrovascular disease -- Prevention -- Saudi Arabia, Heart -- Diseases -- Prevention -- Saudi Arabia, Cytokines | ||||||
Journal or Publication Title: | Nutrients | ||||||
Publisher: | M D P I A G | ||||||
ISSN: | 2072-6643 | ||||||
Official Date: | 6 September 2016 | ||||||
Dates: |
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Volume: | 8 | ||||||
Number: | 9 | ||||||
Article Number: | 460 | ||||||
DOI: | 10.3390/nu8090460 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 4 June 2018 | ||||||
Date of first compliant Open Access: | 4 June 2018 | ||||||
RIOXX Funder/Project Grant: |
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