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The development of CHAMP : a checklist for the appraisal of moderators and predictors
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van Hoorn, Ralph, Tummers, Marcia, Booth, Andrew, Gerhardus, Ansgar, Rehfuess, Eva, Hind, Daniel, Bossuyt, Patrick M., Welch, Vivian, Debray, Thomas P. A., Underwood, Martin, Cuijpers, Pim, Kraemer, Helena, van der Wilt, Gert Jan and Kievit, Wietkse (2017) The development of CHAMP : a checklist for the appraisal of moderators and predictors. BMC Medical Research Methodology, 17 (1). 173. doi:10.1186/s12874-017-0451-0 ISSN 1471-2288.
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Official URL: https://doi.org/10.1186/s12874-017-0451-0
Abstract
BACKGROUND:
Personalized healthcare relies on the identification of factors explaining why individuals respond differently to the same intervention. Analyses identifying such factors, so called predictors and moderators, have their own set of assumptions and limitations which, when violated, can result in misleading claims, and incorrect actions. The aim of this study was to develop a checklist for critically appraising the results of predictor and moderator analyses by combining recommendations from published guidelines and experts in the field.
METHODS:
Candidate criteria for the checklist were retrieved through systematic searches of the literature. These criteria were evaluated for appropriateness using a Delphi procedure. Two Delphi rounds yielded a pilot checklist, which was tested on a set of papers included in a systematic review on reinforced home-based palliative care. The results of the pilot informed a third Delphi round, which served to finalize the checklist.
RESULTS:
Forty-nine appraisal criteria were identified in the literature. Feedback was obtained from fourteen experts from (bio)statistics, epidemiology and other associated fields elicited via three Delphi rounds. Additional feedback from other researchers was collected in a pilot test. The final version of our checklist included seventeen criteria, covering the design (e.g. a priori plausibility), analysis (e.g. use of interaction tests) and results (e.g. complete reporting) of moderator and predictor analysis, together with the transferability of the results (e.g. clinical importance). There are criteria both for individual papers and for bodies of evidence.
CONCLUSIONS:
The proposed checklist can be used for critical appraisal of reported moderator and predictor effects, as assessed in randomized or non-randomized studies using individual participant or aggregate data. This checklist is accompanied by a user's guide to facilitate implementation. Its future use across a wide variety of research domains and study types will provide insights about its usability and feasibility
Item Type: | Journal Article | ||||||||||||
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Subjects: | R Medicine > R Medicine (General) | ||||||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Personalized medicine, Evidence-based medicine, Medical care -- Quality control | ||||||||||||
Journal or Publication Title: | BMC Medical Research Methodology | ||||||||||||
Publisher: | BioMed Central Ltd. | ||||||||||||
ISSN: | 1471-2288 | ||||||||||||
Official Date: | 21 December 2017 | ||||||||||||
Dates: |
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Volume: | 17 | ||||||||||||
Number: | 1 | ||||||||||||
Article Number: | 173 | ||||||||||||
DOI: | 10.1186/s12874-017-0451-0 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 27 March 2018 | ||||||||||||
Date of first compliant Open Access: | 27 March 2018 | ||||||||||||
RIOXX Funder/Project Grant: |
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