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QuimP : analyzing transmembrane signalling in highly deformable cells
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Baniukiewicz, Piotr, Collier, Sharon and Bretschneider, Till (2018) QuimP : analyzing transmembrane signalling in highly deformable cells. Bioinformatics, 34 (15). pp. 2695-2697. bty169. doi:10.1093/bioinformatics/bty169 ISSN 1460-2059.
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Official URL: https://doi.org/10.1093/bioinformatics/bty169
Abstract
Transmembrane signalling plays important physiological roles, with G protein-coupled cell surface receptors being particularly important therapeutic targets. Fluorescent proteins are widely used to study signalling, but analyses of image time series can be challenging, in particular when cells change shape. QuimP software semi-automatically tracks spatio-temporal patterns of fluorescence at the cell membrane at high spatial resolution. This makes it a unique tool for studying transmembrane signalling, particularly during cell migration in immune or cancer cells for example.
Item Type: | Journal Article | ||||||||
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Subjects: | Q Science > QA Mathematics > QA76 Electronic computers. Computer science. Computer software Q Science > QH Natural history > QH301 Biology |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Computer Science | ||||||||
SWORD Depositor: | Library Publications Router | ||||||||
Library of Congress Subject Headings (LCSH): | Bioinformatics -- Software, Cell receptors, G proteins, Cell membranes | ||||||||
Journal or Publication Title: | Bioinformatics | ||||||||
Publisher: | Oxford University Press (OUP) | ||||||||
ISSN: | 1460-2059 | ||||||||
Official Date: | 1 August 2018 | ||||||||
Dates: |
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Volume: | 34 | ||||||||
Number: | 15 | ||||||||
Page Range: | pp. 2695-2697 | ||||||||
Article Number: | bty169 | ||||||||
DOI: | 10.1093/bioinformatics/bty169 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Reuse Statement (publisher, data, author rights): | ** From Crossref via Jisc Publications Router. ** Licence for AM version of this article starting on 16-03-2018: http://creativecommons.org/licenses/by/4.0/ | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 17 April 2018 | ||||||||
Date of first compliant Open Access: | 17 April 2018 | ||||||||
RIOXX Funder/Project Grant: |
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