Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Incidence of superficial venous thrombosis in primary care and risk of subsequent venous thromboembolic sequelae : a retrospective cohort study performed with routine healthcare data from the Netherlands

Tools
- Tools
+ Tools

Geersing, G-J., Cazemier, S., Rutten, F. H., Fitzmaurice, David A. and Hoes, A. W. (2018) Incidence of superficial venous thrombosis in primary care and risk of subsequent venous thromboembolic sequelae : a retrospective cohort study performed with routine healthcare data from the Netherlands. BMJ Open, 8 . e019967. doi:10.1136/bmjopen-2017-019967

[img]
Preview
PDF
WRAP-incidence-superficial-venous-thrombosis-risk-data-Fitzmaurice-2018.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (1629Kb) | Preview
[img] PDF
WRAP-incidence-superficial-venous-thrombosis-primary-care-risk-subsequent-Fitzmaurice-2018.pdf - Accepted Version
Embargoed item. Restricted access to Repository staff only - Requires a PDF viewer.

Download (279Kb)
Official URL: http://doi.org/10.1136/bmjopen-2017-019967

Request Changes to record.

Abstract

Objectives

Recent studies in referred populations of superficial venous thrombosis (SVT) patients report risks of venous thrombo-embolic (VTE) sequela (deep vein thrombosis or pulmonary embolism) as high as 25%. Likely, these estimates are lower in non-referred patients but large-scale population-based studies are lacking. We aimed to estimate the incidence rate of SVT in primary care and quantify its risk of VTE-sequela.

Design

A retrospective cohort study, using International Classification of Primary Care coding (K94.02) combined with free-text searching (synonyms for SVT) to capture all SVT-events. All patients were followed-up for 3 months using manual free-text searching.

Setting

Primary care.

Participants

All patients enlisted with general practitioners within the Utrecht General Practitioner Network between 2010 and 2016 (1,534,845 person-years follow-up).

Main outcome measures

The incidence rate of SVT was expressed as the number of SVT-events per 1000 person-years of follow-up and the 3-month cumulative incidence of VTE-events was calculated. Logistic regression analysis was used to compare SVT patients with and without VTE-sequela.

Results

A total of 2,008 SVT cases were identified, i.e. a SVT incidence rate of 1.31 (95% CI 1.25 to 1.37) per 1000 person-years follow-up, with higher rates notably with increasing age. VTE sequela occurred in 83 patients; 51 at the time of SVT diagnosis and 32 patients during follow-up (total cumulative incidence of 4.1%; 95% CI 3.3% to 5.1%), and were more frequent in those with an active malignancy (OR 2.19; 95% 0.97 to 4.95) and less frequent in those with varicose veins at baseline (OR 0.57, 95% CI 0.34 to 0.94).

Conclusion

We found an incidence rate of SVT in primary care of 1.31 per 1000 person-years. The risks of VTE sequela was relatively low at 4.1%, with the highest risk in cancer patients and in those who experience a SVT in the absence of varicose veins.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences
Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Thrombophlebitis -- Netherlands, Diseases -- Complications -- Netherlands, Primary care (Medicine) -- Netherlands
Journal or Publication Title: BMJ Open
Publisher: BMJ
ISSN: 2044-6055
Official Date: 20 April 2018
Dates:
DateEvent
20 April 2018Published
3 April 2018Accepted
Volume: 8
Article Number: e019967
DOI: 10.1136/bmjopen-2017-019967
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
Related URLs:
  • Publisher

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us