UNSPECIFIED (2003) Concanavalin A application to the olfactory epithelium reveals different sensory neuron populations for the odour pair D- and L-carvone. BEHAVIOURAL BRAIN RESEARCH, 138 (2). pp. 201-206. ISSN 0166-4328

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Abstract

Carvone enantiomers (D and L optical isomers) have been shown to be discriminable by humans even though the odor qualities are quite similar. Our experiment is based on a finding (J. Steroid Biochem. Molec. Biol. 1991;39(4B):621) that Concanavalin A (ConA) applied to a frog olfactory epithelium preparation blocks cAMP transduction induced by D- but not by L-carvone. We used standard operant conditioning methods to train animals to discriminate low odor concentrations Of D-carvone from clean air, to discriminate L-carvone from clean air; or to discriminate between clean air and the odors Of D-carvone, L-carvone, ethyl acetate and methacrylic acid. After perfusion of the nasal cavity with ConA, rats did not respond to D-carvone above or near chance level, while the L-carvone response was not affected at the same or higher ConA doses. However, for rats trained on both enantiomers and the two other unrelated odorants, the D-carvone response remained unaffected by ConA. These results suggest to us that: (1) ConA blocks at least one chiral receptor selective for D-carvone; (2) D-carvone odor quality is modified by ConA so that it is no longer recognized by rats trained on D-carvone only, while rats trained to generalize odors still respond to D-carvone. (C) 2002 Elsevier Science B.V. All rights reserved.

Item Type:	Journal Article
Subjects:	B Philosophy. Psychology. Religion > BF Psychology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Journal or Publication Title:	BEHAVIOURAL BRAIN RESEARCH
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0166-4328
Date:	22 January 2003
Volume:	138
Number:	2
Number of Pages:	6
Page Range:	pp. 201-206
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/10089

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