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Mycobacterial arylamine N-acetyltrasferases and tuberculosis
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Abuhammad, Areej and Fullam, Elizabeth (2018) Mycobacterial arylamine N-acetyltrasferases and tuberculosis. In: Laurieri , Nicola and Sim, Edith, (eds.) Arylamine N-Acetyltransferases in Health and Disease : from Pharmacogenetics to Drug Discovery and Diagnostic. Singapore ; Hackensack, NJ: World Scientific Publishing Co. Pte. Ltd., pp. 385-410. ISBN 9789813232006
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Official URL: https://doi.org/10.1142/9789813232013_0015
Abstract
An N-acetyltransferase (NAT) enzyme has been identified in many mycobacterial species. It has been suggested that the enzyme plays a role in cholesterol degradation and maintaining the homeostasis of acetyl-Coenzyme A, a central metabolite in lipid metabolism. The nat genes from Mycobacterium tuberculosis and Mycobacterium bovis bacillus Calmette–Guerin (BCG) are identical and are encoded in highly similar operons in both organisms (the nat operon). The other genes of the operon are involved in catabolism of the sterol rings of cholesterol. The gene cluster is essential for the survival of M. bovis BCG within macrophages, where cholesterol is likely to be the fuel for intracellular survival. Strains missing these genes are unable to grow on minimal medium with cholesterol, although they retain the ability to grow on rich media.
Item Type: | Book Item | ||||
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||
SWORD Depositor: | Library Publications Router | ||||
Journal or Publication Title: | Arylamine N-acetyltransferases in Health and Disease | ||||
Publisher: | World Scientific Publishing Co. Pte. Ltd. | ||||
Place of Publication: | Singapore ; Hackensack, NJ | ||||
ISBN: | 9789813232006 | ||||
Book Title: | Arylamine N-Acetyltransferases in Health and Disease : from Pharmacogenetics to Drug Discovery and Diagnostic | ||||
Editor: | Laurieri , Nicola and Sim, Edith | ||||
Official Date: | 4 April 2018 | ||||
Dates: |
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Number of Pages: | 456 | ||||
Page Range: | pp. 385-410 | ||||
DOI: | 10.1142/9789813232013_0015 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Reuse Statement (publisher, data, author rights): | ** From Crossref via Jisc Publications Router. | ||||
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