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Bacterial load and molecular markers associated with early-onset Group B Streptococcus
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Seedat, Farah, Brown, Colin Stewart, Stinton, Chris, Patterson, Jacoby, Geppert, Julia, Freeman, Karoline, Tan, Bee K., Johnson, Samantha Ann, Fraser, Hannah, Uthman, Olalekan A., Robinson, Esther R., McCarthy, Noel D., Clarke, Aileen and Taylor-Phillips, Sian (2018) Bacterial load and molecular markers associated with early-onset Group B Streptococcus. The Pediatric infectious disease journal, 37 (12). e306-e314. doi:10.1097/INF.0000000000002050 ISSN 1532-0987.
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WRAP-bacterial-load-molecular-markers-early-onset-Seedat-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1582Kb) | Preview |
Official URL: http://dx.doi.org/10.1097/INF.0000000000002050
Abstract
Background: The natural history of neonatal group B Streptococcus (GBS) is poorly understood. Little is known about the bacterial factors influencing the transmission of GBS from mother to neonate, or the development of invasive early-onset GBS disease (EOGBS) in colonized neonates. We reviewed whether bacterial load and molecular markers are associated with GBS vertical transmission and progression to EOGBS.
Methods: We searched Medline, Embase, Cochrane and Web of Science from inception to 10th October 2016 for observational studies in English. We also hand-searched reference lists of relevant publications and experts cross-checked included studies. Two reviewers independently screened studies, extracted data and appraised the quality of included studies using the QUIPS tool. We conducted random-effects meta-analyses where possible and narratively synthesized the evidence in text and tables.
Results: Seventeen studies were included from 1,107 records retrieved from electronic databases and publication references. Meta-analyses of three studies showed that neonates colonized by serotype III had a higher risk of developing EOGBS than serotype Ia (pooled risk ratio [RR] = 1.51, 95% confidence interval [CI] 1.12 to 2.03) and serotype II (RR = 1.95, 95% CI 1.10 to 3.45). Eleven studies showed that in heavily colonized mothers 2 to 3 times more neonates were colonized, and in heavily colonized neonates up to 15 times more neonates had EOGBS, compared to light colonization. Most evidence was pre-2000 and at risk of bias.
Conclusion: Acknowledging the difficulty of natural history studies, well-controlled studies are needed to assess the predictive value of pathogen subtype and heavy load; they may be useful for better-targeted prevention.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||
| Divisions: | Administration > Information and Digital Group > Library Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Streptococcus agalactiae, Streptococcal infections -- Transmission, Newborn infants -- Diseases, Biochemical markers -- Diagnostic use, Systematic reviews (Medical research) | |||||||||
| Journal or Publication Title: | The Pediatric infectious disease journal | |||||||||
| Publisher: | Lippincott Williams & Wilkins | |||||||||
| ISSN: | 1532-0987 | |||||||||
| Official Date: | December 2018 | |||||||||
| Dates: |
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| Volume: | 37 | |||||||||
| Number: | 12 | |||||||||
| Page Range: | e306-e314 | |||||||||
| DOI: | 10.1097/INF.0000000000002050 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Restricted or Subscription Access | |||||||||
| Date of first compliant deposit: | 12 April 2018 | |||||||||
| Date of first compliant Open Access: | 21 March 2019 | |||||||||
| RIOXX Funder/Project Grant: |
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