UNSPECIFIED (2002) c-MYC: More than just a matter of life and death. Nature, 2 (10). pp. 764-776. ISSN 1474-175X

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Abstract

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.

Item Type:	Journal Item
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Journal or Publication Title:	Nature
Publisher:	NATURE PUBLISHING GROUP
ISSN:	1474-175X
Official Date:	October 2002
Volume:	2
Number:	10
Number of Pages:	13
Page Range:	pp. 764-776
Identification Number:	10.1038/nrc904
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/10126

Data sourced from Thomson Reuters' Web of Knowledge

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