c-MYC: More than just a matter of life and death
UNSPECIFIED (2002) c-MYC: More than just a matter of life and death. Nature, 2 (10). pp. 764-776. ISSN 1474-175XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1038/nrc904
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.
|Item Type:||Journal Item|
|Subjects:||R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)|
|Journal or Publication Title:||Nature|
|Publisher:||NATURE PUBLISHING GROUP|
|Official Date:||October 2002|
|Number of Pages:||13|
|Page Range:||pp. 764-776|
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