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c-MYC: More than just a matter of life and death
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UNSPECIFIED (2002) c-MYC: More than just a matter of life and death. Nature, 2 (10). pp. 764-776. doi:10.1038/nrc904
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Official URL: http://dx.doi.org/10.1038/nrc904
Abstract
Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
| Journal or Publication Title: | Nature | ||||
| Publisher: | NATURE PUBLISHING GROUP | ||||
| ISSN: | 1474-175X | ||||
| Official Date: | October 2002 | ||||
| Dates: |
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| Volume: | 2 | ||||
| Number: | 10 | ||||
| Number of Pages: | 13 | ||||
| Page Range: | pp. 764-776 | ||||
| DOI: | 10.1038/nrc904 | ||||
| Publication Status: | Published |
Data sourced from Thomson Reuters' Web of Knowledge
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