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Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles
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Tang, Shi-Yang, Qiao, Ruirui, Yan, Sheng, Yuan, Dan, Zhao, Quanbin, Yun, Guolin, Davis, Thomas P. and Li, Weihua (2018) Microfluidic mass production of stabilized and stealthy liquid metal nanoparticles. Small, 14 (21). 1800118. doi:10.1002/smll.201800118 ISSN 1613-6810.
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Official URL: https://doi.org/10.1002/smll.201800118
Abstract
Functional nanoparticles comprised of liquid metals, such as eutectic gallium indium (EGaIn) and Galinstan, present exciting opportunities in the fields of flexible electronics, sensors, catalysts, and drug delivery systems. Methods used currently for producing liquid metal nanoparticles have significant disadvantages as they rely on both bulky and expensive high-power sonication probe systems, and also generally require the use of small molecules bearing thiol groups to stabilize the nanoparticles. Herein, we describe an innovative microfluidics-enabled platform as an inexpensive, easily accessible method for the on-chip mass production of EGaIn nanoparticles with tunable size distributions in an aqueous medium. We also report a novel nanoparticle-stabilization approach using brushed polyethylene glycol chains with trithiocarbonate end-groups negating the requirements for thiol additives whilst imparting a ‘stealth’ surface layer. Furthermore, we demonstrate a surface modification of the nanoparticles using galvanic replacement, and conjugation with antibodies. We envision that the demonstrated microfluidic technique can be used as an economic and versatile platform for the rapid production of liquid metal-based nanoparticles for a range of biomedical applications.
Item Type: | Journal Article | ||||||||||||
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Subjects: | Q Science > QC Physics R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||
Library of Congress Subject Headings (LCSH): | Liquid metals, Nanoparticles, Thiols, Gallium, Indium | ||||||||||||
Journal or Publication Title: | Small | ||||||||||||
Publisher: | Wiley - V C H Verlag GmbH & Co. KGaA | ||||||||||||
ISSN: | 1613-6810 | ||||||||||||
Official Date: | 24 May 2018 | ||||||||||||
Dates: |
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Volume: | 14 | ||||||||||||
Number: | 21 | ||||||||||||
Article Number: | 1800118 | ||||||||||||
DOI: | 10.1002/smll.201800118 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Reuse Statement (publisher, data, author rights): | "This is the peer reviewed version of the following article: S.‐Y. Tang, R. Qiao, S. Yan, D. Yuan, Q. Zhao, G. Yun, T. P. Davis, W. Li, Small 2018, 14, 1800118., which has been published in final form at https://doi.org/10.1002/smll.201800118. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions." | ||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||
Date of first compliant deposit: | 19 April 2018 | ||||||||||||
Date of first compliant Open Access: | 22 April 2019 | ||||||||||||
RIOXX Funder/Project Grant: |
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