UNSPECIFIED. (2003) Reduced expression of corticotropin-releasing hormone receptor type-1 alpha and growth-restricted in human preeclamptic placentas. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 88 (1). pp. 363-370. ISSN 0021-972X

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Abstract

Placentally derived CRH seems to play a major role in the mechanisms controlling human pregnancy and parturition, via activation of specific receptors widespread in reproductive tissues. In the human placenta, CRH seems to modulate vasodilation, prostaglandin production, and ACTH secretion. It has also been suggested that CRH might act as a placental clock, determining the length of gestation. In addition, maternal plasma CRH concentrations are further elevated in pregnancies associated with abnormal placental function, such as preeclampsia and intrauterine growth retardation (IUGR). In this study, we sought to investigate the expression of CRH-R1alpha levels in placentas from women who have undergone normal deliveries (control group) and patients who have been diagnosed as having preeclampsia or IUGR. Results showed that placental CRH-R1alpha mRNA levels (as shown by quantitative RT-PCR) and protein levels (shown by Western blotting analysis) were significantly (P < 0.05) reduced in all of the complicated pregnancies. In contrast, levels of the angiotensin II receptor were elevated in preeclampsia and reduced in IUGR subjects, as shown by RT-PCR and Western blotting analysis. These findings might suggest that changes in receptor expression may contribute toward dysregulation of the dynamic balance controlling vascular resistance.

Item Type:	Journal Article
Subjects:	R Medicine > RC Internal medicine
Journal or Publication Title:	JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Publisher:	ENDOCRINE SOC
ISSN:	0021-972X
Date:	January 2003
Volume:	88
Number:	1
Number of Pages:	8
Page Range:	pp. 363-370
Identification Number:	10.1210/jc.2002-020375
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/10133

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