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Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn
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Bastie, Claire C., Zong, Haihong, Xu, Jun, Busa, Bhavin, Judex, Stefan, Kurland, Irwin J. and Pessin, Jeffrey E. (2007) Integrative metabolic regulation of peripheral tissue fatty acid oxidation by the SRC kinase family member Fyn. Cell Metabolism, 5 (5). pp. 371-381. doi:10.1016/j.cmet.2007.04.005 ISSN 1550-4131.
An open access version can be found in:
Official URL: https://doi.org/10.1016/j.cmet.2007.04.005
Abstract
Mice null for Fyn (a member of the Src family of nonreceptor tyrosine kinases) display a reduced percentage of adipose mass associated with decreased adipocyte cell size. In parallel, there is a substantial reduction in fasting plasma glucose, insulin, triglycerides, and free fatty acids concomitant with decreased intrahepatocellular and intramyocellular lipid accumulation. Importantly, the Fyn null mice exhibit improved glucose tolerance resulting from increased peripheral tissue (adipose and skeletal muscle) insulin sensitivity with a very small effect in the liver. Moreover, whole-body, adipose, and skeletal muscle fatty acid uptake and oxidation are increased along with AMP kinase activation and acetyl-CoA carboxylase inhibition. Together, these data demonstrate crosstalk between Src-family kinase activity and fatty acid oxidation and show that the loss of Fyn markedly improves peripheral tissue insulin sensitivity by relieving a selective negative modulation of AMP kinase activity in adipose tissue and skeletal muscle.
| Item Type: | Journal Article | ||||||
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| Subjects: | Q Science > Q Science (General) Q Science > QP Physiology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Cell Metabolism | ||||||
| Publisher: | Cell Press | ||||||
| ISSN: | 1550-4131 | ||||||
| Official Date: | 5 May 2007 | ||||||
| Dates: |
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| Volume: | 5 | ||||||
| Number: | 5 | ||||||
| Page Range: | pp. 371-381 | ||||||
| DOI: | 10.1016/j.cmet.2007.04.005 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||
| Date of first compliant deposit: | 26 April 2018 | ||||||
| Open Access Version: |
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