Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents
UNSPECIFIED. (2003) Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents. JOURNAL OF VIROLOGY, 77 (2). pp. 1237-1244. ISSN 0022-538XFull text not available from this repository.
Official URL: http://dx.doi.org/10.1128/JVI.77.2.1237-1244.2003
We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the MIP-1alpha proinflammatory signaling cascade. Although neither treatment is effective alone, together they offer a dramatic reduction in symptoms and pathology, the most impressive of which is a significant reduction in morbidity and mortality. The findings presented are consistent with the notion of unique and independent contributions of virus replication and ongoing inflammation to the pathogenesis of severe respiratory virus infection, and they provide the impetus for the study of this treatment regimen in RSV-infected humans.
|Item Type:||Journal Article|
|Subjects:||Q Science > QR Microbiology > QR355 Virology|
|Journal or Publication Title:||JOURNAL OF VIROLOGY|
|Publisher:||AMER SOC MICROBIOLOGY|
|Official Date:||January 2003|
|Number of Pages:||8|
|Page Range:||pp. 1237-1244|
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