UNSPECIFIED (2003) Altered pathogenesis of severe pneumovirus infection in response to combined antiviral and specific immunomodulatory agents. JOURNAL OF VIROLOGY, 77 (2). pp. 1237-1244. doi:10.1128/JVI.77.2.1237-1244.2003 ISSN 0022-538X.

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Abstract

We report here the responses of mice with symptomatic pneumovirus infection to combined antiviral and specific immunomodulatory agents. Mice infected with pneumonia virus of mice, a natural mouse pathogen that replicates the signs and symptoms of severe infection with respiratory syncytial virus (RSV), responded to the antiviral agent ribavirin when it was administered in the setting of endogenous (gene deletion) or exogenous (antibody-mediated) blockade of the MIP-1alpha proinflammatory signaling cascade. Although neither treatment is effective alone, together they offer a dramatic reduction in symptoms and pathology, the most impressive of which is a significant reduction in morbidity and mortality. The findings presented are consistent with the notion of unique and independent contributions of virus replication and ongoing inflammation to the pathogenesis of severe respiratory virus infection, and they provide the impetus for the study of this treatment regimen in RSV-infected humans.

Item Type:	Journal Article
Subjects:	Q Science > QR Microbiology > QR355 Virology
Journal or Publication Title:	JOURNAL OF VIROLOGY
Publisher:	AMER SOC MICROBIOLOGY
ISSN:	0022-538X
Official Date:	January 2003
Dates:	Date Event January 2003 UNSPECIFIED
Volume:	77
Number:	2
Number of Pages:	8
Page Range:	pp. 1237-1244
DOI:	10.1128/JVI.77.2.1237-1244.2003
Publication Status:	Published

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