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Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex
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Sanchez-Cano, Carlos, Romero-Canelón, Isolda, Gerakic, Kalotina and Sadler, P. J. (2018) Microfocus x-ray fluorescence mapping of tumour penetration by an organo-osmium anticancer complex. Journal of Inorganic Biochemistry, 185 . pp. 26-29. doi:10.1016/j.jinorgbio.2018.04.014 ISSN 0162-0134.
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Official URL: https://doi.org/10.1016/j.jinorgbio.2018.04.014
Abstract
Microfocus synchrotron x-ray fluorescence (SXRF) imaging focussed on detection of the Os LIII edge shows that the organo-osmium metallodrug candidate [(ŋ6-pcym)Os(Azpy-NMe2)I]+ (p-cym = p-cymene, Azpy-NMe2 = 2-(p-([dimethylamino]phenylazo)pyridine)) [1] penetrates efficiently into the interior of A2780 human ovarian cancer cell spheroids, a model for a solid tumour. The accompanying changes in Zn and Ca distribution suggest that the complex causes nuclear damage and initiates signalling events for cell death, consistent with findings for cultured cancer cell monolayers. Such tumour penetration is likely to be important for combatting resistance to chemotherapy, which is becoming a problem for current clinical platinum drugs.
Item Type: | Journal Article | ||||||||||||
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Subjects: | R Medicine > RC Internal medicine R Medicine > RS Pharmacy and materia medica |
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Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry | ||||||||||||
Library of Congress Subject Headings (LCSH): | Antineoplastic agents, Organolithium compounds, X-ray spectroscopy | ||||||||||||
Journal or Publication Title: | Journal of Inorganic Biochemistry | ||||||||||||
Publisher: | Elsevier Science Inc | ||||||||||||
ISSN: | 0162-0134 | ||||||||||||
Official Date: | August 2018 | ||||||||||||
Dates: |
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Volume: | 185 | ||||||||||||
Page Range: | pp. 26-29 | ||||||||||||
DOI: | 10.1016/j.jinorgbio.2018.04.014 | ||||||||||||
Status: | Peer Reviewed | ||||||||||||
Publication Status: | Published | ||||||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||||||
Date of first compliant deposit: | 2 May 2018 | ||||||||||||
Date of first compliant Open Access: | 3 May 2018 | ||||||||||||
RIOXX Funder/Project Grant: |
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