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Data for Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica: date estimation 2

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Zhou, Zhemin, Lundstrøm, Inge, Dien, Alicia Tran, Duchêne, Sebastián, Alikhan, Nabil-Fareed, Sergeant, Martin J., Langridge, Gemma, Fotakis, Anna K., Nair, Satheesh, Stenøien, Hans K., Hamre, Stian S., Casjens, Sherwood, Quince, Christopher , Christophersen, Axel, Thomson, Nicholas R., Weill, François-Xavier, Ho, Simon, Gilbert, M. Thomas P. and Achtman, Mark (2018) Data for Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica: date estimation 2. [Dataset]

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PDF (Linear regression plots (TempEst [37]) of root-to-tip genetic distances to the MRCA of two sets of modern genomes plus Ragna (red), Tepos-14 and Tepos-35 (green) [19] versus their dates of sampling.)
Date estimation 2.pdf - Published Version - Requires a PDF viewer.
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Abstract

Salmonella enterica serovar Paratyphi C is the causative agent of enteric (paratyphoid) fever. While today a potentially lethal infection of humans that occurs in Africa and Asia, early 20th century observations in Eastern Europe suggest it may once have had a wider-ranging impact on human societies. We recovered a draft Paratyphi C genome from the 800-year-old skeleton of a young woman in Trondheim, Norway, who likely died of enteric fever. Analysis of this genome against a new, significantly expanded database of related modern genomes demonstrated that Paratyphi C is descended from the ancestors of swine pathogens, serovars Choleraesuis and Typhisuis, together forming the Para C Lineage. Our results indicate that Paratyphi C has been a pathogen of humans for at least 1,000 years, and may have evolved after zoonotic transfer from swine during the Neolithic period.

Item Type: Dataset
Subjects: Q Science > QR Microbiology
Divisions: Faculty of Medicine > Warwick Medical School
Type of Data: Charts
Library of Congress Subject Headings (LCSH): Typhoid fever -- Genetic aspects -- History, Typhoid fever -- Trondheim (Norway) -- 13th century
Publisher: Warwick Medical School, University of Warwick
Official Date: 4 May 2018
Dates:
DateEvent
4 May 2018Published
Date of first compliant deposit: 2 May 2018
Status: Not Peer Reviewed
Publication Status: Published
Media of Output: .pdf
Access rights to Published version: Open Access
Copyright Holders: University of Warwick
Description:

Linear regression plots (TempEst [37]) of root-to-tip genetic distances to the MRCA of two sets of modern genomes plus Ragna (red), Tepos-14 and Tepos-35 (green) [19] versus their dates of sampling.

RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
BB/L020319/1Biotechnology and Biological Sciences Research Councilhttp://dx.doi.org/10.13039/501100000268
202792/Z/16/ZWellcome Trusthttp://dx.doi.org/10.13039/100004440
DNRF 94Danmarks Grundforskningsfondhttp://dx.doi.org/10.13039/501100001732
R52-5062Lundbeckfondenhttp://dx.doi.org/10.13039/501100003554
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  • Related item in WRAP
Contributors:
ContributionNameContributor ID
DepositorZhou, Zhemin58084

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