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Data for Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica: date estimation 2
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Zhou, Zhemin, Lundstrøm, Inge, Dien, Alicia Tran, Duchêne, Sebastián, Alikhan, Nabil-Fareed, Sergeant, Martin J., Langridge, Gemma, Fotakis, Anna K., Nair, Satheesh, Stenøien, Hans K., Hamre, Stian S., Casjens, Sherwood, Quince, Christopher , Christophersen, Axel, Thomson, Nicholas R., Weill, François-Xavier, Ho, Simon, Gilbert, M. Thomas P. and Achtman, Mark (2018) Data for Millennia of genomic stability within the invasive Para C Lineage of Salmonella enterica: date estimation 2. [Dataset]
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PDF (Linear regression plots (TempEst [37]) of root-to-tip genetic distances to the MRCA of two sets of modern genomes plus Ragna (red), Tepos-14 and Tepos-35 (green) [19] versus their dates of sampling.)
Date estimation 2.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (109Kb) | Preview |
Abstract
Salmonella enterica serovar Paratyphi C is the causative agent of enteric (paratyphoid) fever. While today a potentially lethal infection of humans that occurs in Africa and Asia, early 20th century observations in Eastern Europe suggest it may once have had a wider-ranging impact on human societies. We recovered a draft Paratyphi C genome from the 800-year-old skeleton of a young woman in Trondheim, Norway, who likely died of enteric fever. Analysis of this genome against a new, significantly expanded database of related modern genomes demonstrated that Paratyphi C is descended from the ancestors of swine pathogens, serovars Choleraesuis and Typhisuis, together forming the Para C Lineage. Our results indicate that Paratyphi C has been a pathogen of humans for at least 1,000 years, and may have evolved after zoonotic transfer from swine during the Neolithic period.
| Item Type: | Dataset | |||||||||||||||
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| Subjects: | Q Science > QR Microbiology | |||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School | |||||||||||||||
| Type of Data: | Charts | |||||||||||||||
| Library of Congress Subject Headings (LCSH): | Typhoid fever -- Genetic aspects -- History, Typhoid fever -- Trondheim (Norway) -- 13th century | |||||||||||||||
| Publisher: | Warwick Medical School, University of Warwick | |||||||||||||||
| Official Date: | 4 May 2018 | |||||||||||||||
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| Date of first compliant deposit: | 2 May 2018 | |||||||||||||||
| Status: | Not Peer Reviewed | |||||||||||||||
| Publication Status: | Published | |||||||||||||||
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| Access rights to Published version: | Open Access | |||||||||||||||
| Copyright Holders: | University of Warwick | |||||||||||||||
| Description: | Linear regression plots (TempEst [37]) of root-to-tip genetic distances to the MRCA of two sets of modern genomes plus Ragna (red), Tepos-14 and Tepos-35 (green) [19] versus their dates of sampling. |
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