Dimitriadis, Georgios K. and Miras, Alexander D. (2018) Glucagon like peptide 2 (GLP-2). In: Huhtaniemi, Ilpo, (ed.) Encyclopedia of Endocrine Diseases. Elsevier Academic Press. ISBN 9780128121993 (In Press)

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Abstract

The role of the gastrointestinal (GI) tract in energy homeostasis through the digestion and absorption of carbohydrates, and the production of incretin hormones remains well recognized in recent years. Studying the functional changes of the GI system following bariatric surgery; particularly involving the secretion of incretin hormones has led into understanding their interaction with arears of the brain to regulate metabolism and energy balance. In Type 2 Diabetes Mellitus (T2DM) and obesity, this homeostatic balance is disrupted, either through alterations in the levels of these hormones or through resistance to their actions. Although bariatric surgery is an effective treatment for T2DM and obesity, it cannot be applied to most patients. Hence, recapitulation of the changes of incretin hormone secretion after bariatric surgery in the post Glucagon-like peptide 1 (GLP-1) analogue era remains an attractive area for further research and the development of new treatments for T2DM and obesity.
Glucagon-like peptide 2 (GLP-2) is a proglucagon-derived peptide produced by intestinal L-cells and by cells within the brainstem and other areas of the central nervous system. GLP-2 is implicated in regulation of energy absorption and maintenance of GI mucosal structure but as recent evidence suggests may also have a beneficial effect in glucose homeostasis, particularly in states associated with increased energy uptake such as obesity.

Item Type:	Book Item
Subjects:	Q Science > QP Physiology R Medicine > R Medicine (General) R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Warwick Medical School > Biomedical Sciences Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine > Metabolic and Vascular Health (- until July 2016) Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Medicine > Warwick Medical School
Publisher:	Elsevier Academic Press
ISBN:	9780128121993
Book Title:	Encyclopedia of Endocrine Diseases
Editor:	Huhtaniemi, Ilpo
Official Date:	1 October 2018
Dates:	Date Event 1 October 2018 Published
Date of first compliant deposit:	7 May 2018
Number of Pages:	4000
Status:	Not Peer Reviewed
Publication Status:	In Press
Access rights to Published version:	Restricted or Subscription Access
Related URLs:	Publisher

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