Venkatesh, Venkatesh and Sadler, P. J. (2018) Platinum(IV) prodrugs. In: Sigel, Astrid and Sigel, Helmut and Freisinger, Eva and Sigel, Roland K.O., (eds.) Metallo-Drugs: Development and Action of Anticancer Agents. Metal Ions in Life Sciences, 18 . De Gruyter, pp. 69-108. ISBN 9783110470734
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Abstract
This chapter is an overview of recent progress in the design of Pt(IV) prodrugs. These kinetically-inert octahedral prodrugs can be reduced in cancer cells to active squareplanar Pt(II) complexes, for example by intracellular reducing agents such as glutathione or by photoexcitation. The additional axial ligands in Pt(IV) complexes which are released on reduction, allow bioactive molecules to be delivered which can act synergistically with Pt(II) in killing cancer cells, or act as targeting vectors, allow attachment to polymer and nanoparticle delivery systems, or labelling with fluorescent probes. Pt(IV) prodrugs have yet to be approved for clinical use, although some offer the promise of increased efficacy and reduced side effects.
| Item Type: | Book Item |
|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry |
| Series Name: | Metal Ions in Life Sciences |
| Publisher: | De Gruyter |
| ISBN: | 9783110470734 |
| Book Title: | Metallo-Drugs: Development and Action of Anticancer Agents |
| Editor: | Sigel, Astrid and Sigel, Helmut and Freisinger, Eva and Sigel, Roland K.O. |
| Official Date: | 2018 |
| Dates: | Date Event 2018 UNSPECIFIED |
| Volume: | 18 |
| Page Range: | pp. 69-108 |
| DOI: | 10.1515/9783110470734-009 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| URI: | https://wrap.warwick.ac.uk/101947/ |
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