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Effectiveness of live attenuated influenza vaccine in preventing amoxicillin prescribing in preschool children : a self-controlled case series study
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Hardelid, Pia, Ghebremichael Weldeselassie, Yonas, Whitaker, Heather, Rait, Greta, Gilbert, Ruth and Petersen, Irene (2018) Effectiveness of live attenuated influenza vaccine in preventing amoxicillin prescribing in preschool children : a self-controlled case series study. Journal of Antimicrobial Chemotherapy, 73 (3). pp. 779-786. doi:10.1093/jac/dkx463 ISSN 0305-7453.
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WRAP-effectiveness-live-attenuated-influenza-vaccine-preventing-amoxicillin-prescribing-preschool-children-Ghebremichael-Weldeselassie-2018.pdf - Accepted Version - Requires a PDF viewer. Download (1048Kb) | Preview |
Official URL: http://dx.doi.org/10.1093/jac/dkx463
Abstract
Objectives
To determine the effectiveness of live attenuated influenza vaccine (LAIV) in reducing amoxicillin prescribing in preschool children in primary care.
Patients and methods
We used The Health Improvement Network (THIN), a large primary care database from the United Kingdom. We included children aged 2 to 4 years old at the start of either the 2013/14 or the 2014/15 winter season, with at least one amoxicillin prescription between September and May, irrespective of LAIV vaccination status. We used the self-controlled case series method to estimate influenza vaccine effectiveness (VE).
Results
The total study sample included 33 137 children from 378 general practices during the two winter seasons. Of these children, 43.4% with at least one amoxicillin prescription had been vaccinated. The rate of amoxicillin prescribing was significantly reduced during periods of influenza vaccine immunity. The associated VE for amoxicillin prescribing was 12.8% (95% CI 6.9%, 18.3%) in 2013/14 and 14.5% (9.6%, 19.2%) in 2014/15. Given a VE of 14.5%, we estimated that amoxicillin prescribing could have been reduced by 5.6% if LAIV uptake in children aged 2–4 years increased to 50% in the 2014/15 winter season.
Conclusions
Influenza vaccination of young children may contribute to a reduction in the prescribing of amoxicillin, one of the most commonly prescribed antibiotics in primary care. Further studies are required to confirm the size of the effect.
| Item Type: | Journal Article | ||||||||
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| Subjects: | Q Science > QR Microbiology > QR180 Immunology R Medicine > RM Therapeutics. Pharmacology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Influenza vaccines, Amoxicillin | ||||||||
| Journal or Publication Title: | Journal of Antimicrobial Chemotherapy | ||||||||
| Publisher: | Oxford University Press | ||||||||
| ISSN: | 0305-7453 | ||||||||
| Official Date: | 1 March 2018 | ||||||||
| Dates: |
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| Volume: | 73 | ||||||||
| Number: | 3 | ||||||||
| Page Range: | pp. 779-786 | ||||||||
| DOI: | 10.1093/jac/dkx463 | ||||||||
| Status: | Peer Reviewed | ||||||||
| Publication Status: | Published | ||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||
| Date of first compliant deposit: | 16 July 2018 | ||||||||
| Date of first compliant Open Access: | 8 December 2018 | ||||||||
| RIOXX Funder/Project Grant: |
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