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Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis : a magnetic resonance spectroscopic imaging study
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MS-SMART Trialists (Including: Marshall, Ian, Thrippleton, Michael J., Bastin, Mark E., Mollison, Daisy, Dickie, David A., Chappell, Francesca M., Semple , Scott I. K., Cooper, Annette, Pavitt, Sue, Giovannoni, Gavin, Wheeler-Kingshott, Claudia A. M. Gandini , Solanky, Bhavana S., Weir, Christopher J., Stallard, Nigel, Hawkins, Clive, Sharrack, Basil, Chataway, Jeremy, Connick, Peter and Chandran, Siddharthan). (2018) Characterisation of tissue-type metabolic content in secondary progressive multiple sclerosis : a magnetic resonance spectroscopic imaging study. Journal of Neurology, 265 (8). pp. 1795-1802. doi:10.1007/s00415-018-8903-y ISSN 0340-5354.
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Official URL: https://doi.org/10.1007/s00415-018-8903-y
Abstract
Proton magnetic resonance spectroscopy yields metabolic information and has proved to be a useful addition to structural imaging in neurological diseases. We applied short-echo time Spectroscopic Imaging in a cohort of 42 patients with secondary progressive multiple sclerosis (SPMS). Linear modelling with respect to brain tissue type yielded metabolite levels that were significantly different in white matter lesions compared with normal-appearing white matter, suggestive of higher myelin turnover (higher choline), higher metabolic rate (higher creatine) and increased glial activity (higher myo-inositol) within the lesions. These findings suggest that the lesions have ongoing cellular activity that is not consistent with the usual assumption of ‘chronic’ lesions in SPMS, and may represent a target for repair therapies.
Item Type: | Journal Article | |||||||||||||||
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Subjects: | Q Science > QP Physiology R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Multiple sclerosis -- Research, Proton magnetic resonance spectroscopy, White matter | |||||||||||||||
Journal or Publication Title: | Journal of Neurology | |||||||||||||||
Publisher: | Springer Medizin | |||||||||||||||
ISSN: | 0340-5354 | |||||||||||||||
Official Date: | August 2018 | |||||||||||||||
Dates: |
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Volume: | 265 | |||||||||||||||
Number: | 8 | |||||||||||||||
Page Range: | pp. 1795-1802 | |||||||||||||||
DOI: | 10.1007/s00415-018-8903-y | |||||||||||||||
Status: | Peer Reviewed | |||||||||||||||
Publication Status: | Published | |||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | |||||||||||||||
Date of first compliant deposit: | 11 May 2018 | |||||||||||||||
Date of first compliant Open Access: | 15 October 2018 | |||||||||||||||
RIOXX Funder/Project Grant: |
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