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Friction forces position the neural anlage
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Smutny, Michael, Ákos, Zsuzsa, Grigolon, Silvia, Shamipour, Shayan, Ruprecht, Verena, Čapek, Daniel, Behrndt, Martin, Papusheva, Ekaterina, Tada, Masazumi, Hof, Björn, Vicsek, Tamás, Salbreux, Guillaume and Heisenberg, Carl-Philipp (2017) Friction forces position the neural anlage. Nature Cell Biology, 19 (4). pp. 306-317. doi:10.1038/ncb3492 ISSN 1465-7392.
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Official URL: http://dx.doi.org/10.1038/ncb3492
Abstract
During embryonic development, mechanical forces are essential for cellular rearrangements driving tissue morphogenesis. Here, we show that in the early zebrafish embryo, friction forces are generated at the interface between anterior axial mesoderm (prechordal plate, ppl) progenitors migrating towards the animal pole and neurectoderm progenitors moving in the opposite direction towards the vegetal pole of the embryo. These friction forces lead to global rearrangement of cells within the neurectoderm and determine the position of the neural anlage. Using a combination of experiments and simulations, we show that this process depends on hydrodynamic coupling between neurectoderm and ppl as a result of E-cadherin-mediated adhesion between those tissues. Our data thus establish the emergence of friction forces at the interface between moving tissues as a critical force-generating process shaping the embryo.
Item Type: | Journal Article | ||||||||||||||||||||||||
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Subjects: | Q Science > QH Natural history Q Science > QL Zoology |
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Embryology, Morphogenesis, Tissue remodeling, Zebra danio -- Morphogenesis | ||||||||||||||||||||||||
Journal or Publication Title: | Nature Cell Biology | ||||||||||||||||||||||||
Publisher: | Nature Publishing Group | ||||||||||||||||||||||||
ISSN: | 1465-7392 | ||||||||||||||||||||||||
Official Date: | 27 March 2017 | ||||||||||||||||||||||||
Dates: |
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Volume: | 19 | ||||||||||||||||||||||||
Number: | 4 | ||||||||||||||||||||||||
Page Range: | pp. 306-317 | ||||||||||||||||||||||||
DOI: | 10.1038/ncb3492 | ||||||||||||||||||||||||
Status: | Peer Reviewed | ||||||||||||||||||||||||
Publication Status: | Published | ||||||||||||||||||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||
Date of first compliant deposit: | 3 January 2019 | ||||||||||||||||||||||||
Date of first compliant Open Access: | 3 January 2019 | ||||||||||||||||||||||||
Funder: | Austria. Bundesministerium für Unterricht und Kunst , Spain. Ministerio de Economía y Competitividad [Ministry of Economy and Competitiveness] (MINECO), Centres de Recerca de Catalunya [Research Centers of Catalonia] (CERCA) | ||||||||||||||||||||||||
Grant number: | OMAA Ernst Mach Predoctoral Scholarship ; Centro de Excelencia Severo Ochoa 2013-2017 | ||||||||||||||||||||||||
RIOXX Funder/Project Grant: |
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