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Neighborly relations : cadherins and mechanotransduction

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Smutny, Michael and Yap, Alpha S. (2010) Neighborly relations : cadherins and mechanotransduction. The Journal of Cell Biology, 189 (7). pp. 1075-1077. doi:10.1083/jcb.201005151

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Official URL: http://dx.doi.org/10.1083/jcb.201005151

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Abstract

Cell–cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell–cell contacts. In this issue, Le Duc et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force.

Item Type: Journal Item
Divisions: Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology
Faculty of Medicine > Warwick Medical School > Biomedical Sciences
Journal or Publication Title: The Journal of Cell Biology
Publisher: Rockefeller University Press
ISSN: 0021-9525
Official Date: 2010
Dates:
DateEvent
2010Published
Volume: 189
Number: 7
Page Range: pp. 1075-1077
DOI: 10.1083/jcb.201005151
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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