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Neighborly relations : cadherins and mechanotransduction
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Smutny, Michael and Yap, Alpha S. (2010) Neighborly relations : cadherins and mechanotransduction. The Journal of Cell Biology, 189 (7). pp. 1075-1077. doi:10.1083/jcb.201005151
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Official URL: http://dx.doi.org/10.1083/jcb.201005151
Abstract
Cell–cell adhesions are sites where cells experience and resist tugging forces. It has long been postulated, but not directly tested, that cadherin adhesion molecules may serve in mechanotransduction at cell–cell contacts. In this issue, Le Duc et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001149) provide direct evidence that E-cadherin participates in a mechanosensing pathway that regulates the actomyosin cytoskeleton to modulate cell stiffness in response to pulling force.
| Item Type: | Journal Item | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Biomedical Sciences > Cell & Developmental Biology Faculty of Medicine > Warwick Medical School > Biomedical Sciences |
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| Journal or Publication Title: | The Journal of Cell Biology | ||||
| Publisher: | Rockefeller University Press | ||||
| ISSN: | 0021-9525 | ||||
| Official Date: | 2010 | ||||
| Dates: |
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| Volume: | 189 | ||||
| Number: | 7 | ||||
| Page Range: | pp. 1075-1077 | ||||
| DOI: | 10.1083/jcb.201005151 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
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