The Library
Correlation between neonatal outcomes of twins depends on the outcome : secondary analysis of twelve randomised controlled trials
Tools
Tools
Tools
Yelland, Lisa N., Schuit, Ewoud, Zamora, Javier, Middleton, Philippa F., Lim, Arianne C., Nassar, Anwar H., Rode, Line, Serra, Vicente, Thom, Elizabeth A., Vayssière, Christophe, Mol, Ben W. J. and Gates, Simon (2018) Correlation between neonatal outcomes of twins depends on the outcome : secondary analysis of twelve randomised controlled trials. BJOG: An International Journal of Obstetrics & Gynaecology . doi:10.1111/1471-0528.15292
Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1111/1471-0528.15292
Abstract
Objective
To estimate the magnitude of the correlation between neonatal outcomes of twins and demonstrate how this information can be used in the design of randomised controlled trials (RCTs) in women with twin pregnancies.
Design
Secondary analysis of data from 12 RCTs.
Setting
Obstetric care in multiple countries, 2004‐2012.
Population or Sample
4504 twin pairs born to women who participated in RCTs to assess treatments given during pregnancy.
Methods
Intraclass correlation coefficients (ICCs) were estimated using log binomial and linear models.
Main Outcome Measures
Perinatal death, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular haemorrhage, necrotising enterocolitis, sepsis, neonatal intensive care unit admission, birthweight, low birthweight and two composite measures of adverse neonatal outcome.
Results
ICCs for the composite measures of adverse neonatal outcome were all above 0.5, indicating moderate to strong correlation between adverse outcomes of twins. For individual neonatal outcomes, median ICCs across trials ranged from 0.13 to 0.79 depending on the outcome. An example illustrates how ICCs can be used in sample size calculations for RCTs in women with twin pregnancies.
Conclusions
The correlation between neonatal outcomes of twins varies considerably between outcomes and may be lower than expected. Our ICC estimates can be used for designing and analysing RCTs that recruit women with twin pregnancies and performing meta‐analyses that include such RCTs. Researchers are encouraged to report ICCs for neonatal outcomes in twins in their own RCTs.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
||||
| SWORD Depositor: | Library Publications Router | ||||
| Journal or Publication Title: | BJOG: An International Journal of Obstetrics & Gynaecology | ||||
| Publisher: | Wiley-Blackwell Publishing, Inc | ||||
| ISSN: | 1470-0328 | ||||
| Official Date: | 22 May 2018 | ||||
| Dates: |
|
||||
| DOI: | 10.1111/1471-0528.15292 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access |
Request changes or add full text files to a record
Repository staff actions (login required)
 |
View Item |
