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Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity : a matched case-control analysis
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Owusu Adjah, Ebenezer S., Bellary, Srikanth, Hanif, Wasim, Patel, Kiran, Khunti, Kamlesh and Paul, Sanjoy K. (2018) Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity : a matched case-control analysis. Cardiovascular Diabetology, 17 (1). 70. doi:10.1186/s12933-018-0712-1 ISSN 1475-2840.
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WRAP-prevalence-incidence-complications-diagnosis-ethnicity-analysis-Patel-2018.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (1599Kb) | Preview |
Official URL: https://doi.org/10.1186/s12933-018-0712-1
Abstract
To estimate the risk of developing long-term major cardiovascular and renal complications in relation to levels of body mass index (BMI) in a population of White European (WE), African-Caribbean (AC), and South Asian (SA) patients with type 2 diabetes mellitus (T2DM). Patients with new diagnosis of T2DM, aged ≥ 18 years from January 2000 (n = 69,436) and their age-sex-ethnicity matched non-diabetic controls (n = 272,190) were identified from UK primary care database. Incidence rates ratios (IRRs) for non-fatal major cardiovascular events (MACE) and chronic kidney disease (CKD) in patients with T2DM compared to controls were estimated using multivariate Mantel-Cox model. Among normal weight patients with T2DM, WEs had significantly higher prevalence of cardiovascular multi-morbidity (95% CI 9.5, 11.3), compared to SAs (95% CI 4.8, 9.5). AC and SA overweight and obese patients had similar prevalence, while obese WEs had significantly higher prevalence. During a median 7 years of follow-up, risk of MACE was significantly higher for overweight (95% CI of IRR 1.50, 2.46) and obese (95% CI of IRR 1.49, 2.43) SAs compared to their WE counterparts. However, similar risk levels were observed for normal weight WEs and SAs, respectively. Risk of CKD was higher and uniform for BMI ≥ 25 kg/m amongst WEs and ACs, whereas only overweight patients had significantly higher risk of CKD amongst SA [IRR 2.08 (95% CI 1.49, 2.93)]. Risk of MACE/CKD varies over levels of BMI within each ethnic group, with overweight SAs having a disproportionate risk of CKD.
| Item Type: | Journal Article | ||||||
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| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Dean's Office & Professional Support Services Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||
| Journal or Publication Title: | Cardiovascular Diabetology | ||||||
| Publisher: | Biomed central | ||||||
| ISSN: | 1475-2840 | ||||||
| Official Date: | 15 May 2018 | ||||||
| Dates: |
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| Volume: | 17 | ||||||
| Number: | 1 | ||||||
| Article Number: | 70 | ||||||
| DOI: | 10.1186/s12933-018-0712-1 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 5 June 2018 | ||||||
| Date of first compliant Open Access: | 5 June 2018 |
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