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Bidirectional association between disturbed sleep and neuropathic pain symptoms : a prospective cohort study in post-total joint replacement participants
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Stocks, Joanne, Tang, Nicole K. Y., Walsh, David A., Warner, Sophie C., Harvey, Hollie, Jenkins, Wendy, Abhishek, Abhishek, Doherty, Michael and Valdes, Ana M. (2018) Bidirectional association between disturbed sleep and neuropathic pain symptoms : a prospective cohort study in post-total joint replacement participants. Journal of Pain Research, 2018 (11). pp. 1087-1093. doi:10.2147/JPR.S149830
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Official URL: https://doi.org/10.2147/JPR.S149830
Abstract
Background
Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic-like pain symptoms.
Methods
A total of 423 individuals who had undergone total joint replacement (TJR) for osteoarthritis were assessed at the mean time of 3.6 years post-surgery and again at 5.9 years post-TJR, using the Medical Outcomes Survey sleep subscale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and painDETECT questionnaire instruments. Cox hazard ratios (HRs) and 95% confidence intervals (CIs) were computed adjusting for age, body mass index, sex, and use of hypnotic and analgesic medication.
Results
The presence of neuropathic pain symptoms predicted incidence of disturbed sleep after adjustment for covariates and pain severity (adjusted HR [aHR] 2.01, 95% CI: 1.00–4.10; p<0.05). There was no association between joint pain and incidence of disturbed sleep when individuals with neuropathic pain symptoms at the baseline visit were excluded (aHR 1.11, 95% CI: 0.47–2.67). Disturbed sleep at baseline predicted incident neuropathic joint pain symptoms (aHR 2.75, 95% CI: 1.21–6.26; p<0.016) but had no effect on incidence of joint pain when all types of pain were considered together (aHR 0.63, 95% CI: 0.30–1.39).
Conclusion
These data suggest a causal bidirectional link between sleep disturbance and joint pain with neuropathic features but not with other types of joint pain.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RD Surgery | ||||||
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Psychology | ||||||
| Library of Congress Subject Headings (LCSH): | Artificial joints, Total hip replacement, Total knee replacement, Opioids, Osteoarthritis | ||||||
| Journal or Publication Title: | Journal of Pain Research | ||||||
| Publisher: | Dove Medical Press Ltd | ||||||
| ISBN: | 1178-7090 | ||||||
| Official Date: | 6 June 2018 | ||||||
| Dates: |
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| Volume: | 2018 | ||||||
| Number: | 11 | ||||||
| Page Range: | pp. 1087-1093 | ||||||
| DOI: | 10.2147/JPR.S149830 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Open Access (Creative Commons) | ||||||
| Date of first compliant deposit: | 18 October 2018 | ||||||
| Date of first compliant Open Access: | 18 October 2018 | ||||||
| RIOXX Funder/Project Grant: |
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