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Associations of maternal Vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight : a systematic review and meta-analysis of individual participant data
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(2017) Associations of maternal Vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight : a systematic review and meta-analysis of individual participant data. American Journal of Epidemiology, 185 (3). pp. 212-223. doi:10.1093/aje/kww212 ISSN 0002-9262.
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Official URL: http://dx.doi.org/10.1093/aje/kww212
Abstract
Vitamin B12 (hereafter referred to as B12) deficiency in pregnancy is prevalent and has been associated with both lower birth weight (birth weight <2,500 g) and preterm birth (length of gestation <37 weeks). Nevertheless, current evidence is contradictory. We performed a systematic review and a meta-analysis of individual participant data to evaluate the associations of maternal serum or plasma B12 concentrations in pregnancy with offspring birth weight and length of gestation. Twenty-two eligible studies were identified (11,993 observations). Eighteen studies were included in the meta-analysis (11,216 observations). No linear association was observed between maternal B12 levels in pregnancy and birth weight, but B12 deficiency (<148 pmol/L) was associated with a higher risk of low birth weight in newborns (adjusted risk ratio = 1.15, 95% confidence interval (CI): 1.01, 1.31). There was a linear association between maternal levels of B12 and preterm birth (per each 1-standard-deviation increase in B12, adjusted risk ratio = 0.89, 95% CI: 0.82, 0.97). Accordingly, B12 deficiency was associated with a higher risk of preterm birth (adjusted risk ratio = 1.21, 95% CI: 0.99, 1.49). This finding supports the need for randomized controlled trials of vitamin B12 supplementation in pregnancy.
Item Type: | Journal Article | ||||||
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Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | American Journal of Epidemiology | ||||||
Publisher: | Oxford University Press | ||||||
ISSN: | 0002-9262 | ||||||
Official Date: | 1 February 2017 | ||||||
Dates: |
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Volume: | 185 | ||||||
Number: | 3 | ||||||
Page Range: | pp. 212-223 | ||||||
DOI: | 10.1093/aje/kww212 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) |
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