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The association between obstructive sleep apnea and metabolic abnormalities in women with polycystic ovary syndrome : a systematic review and meta-analysis
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Kahal, Hassan, Kyrou, Ioannis, Uthman, Olalekan A., Brown, Anna, Johnson, Samantha Ann, Wall, Peter D. H., Metcalfe, Andrew J., Tahrani, Abd A. (Almagid) and Randeva, Harpal S. (2018) The association between obstructive sleep apnea and metabolic abnormalities in women with polycystic ovary syndrome : a systematic review and meta-analysis. Sleep, 41 (7). zsy085. doi:10.1093/sleep/zsy085 ISSN 1550-9109.
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Official URL: http://dx.doi.org/10.1093/sleep/zsy085
Abstract
STUDY OBJECTIVES:
In this systematic review and meta-analysis, we aimed to examine the relationship between obstructive sleep apnoea (OSA) and metabolic abnormalities in women with polycystic ovary syndrome (PCOS).
METHODS:
Electronic databases (Medline, Embase, Cinahl, PsycInfo, Scopus, Web of Science, Opengrey, CENTRAL), conference abstracts, and reference lists of relevant articles were searched. No restriction was applied for language or publication status.
RESULTS:
Six studies involving 252 participants were included. Women with PCOS and OSA had significantly higher body mass index (mean difference [MD]: 6.01 kg/m 2, 95% Confidence Intervals [CI]: 4.69-7.33), waist circumference (MD: 10.93 cm, 95% CI: 8.03-13.83), insulin resistance, systolic and diastolic blood pressure, as well as worse lipids' profile and impaired glucose regulation compared to women with PCOS without OSA. Most studies did not adjust for weight in their between groups analysis. Total and free testosterone levels were not significantly different between the two groups. The majority of studies were found to be at high risk of selection bias; did not account for important confounders; were conducted in one country (USA); and used different methodologies to assess testosterone levels (preventing a meta-analysis for this specific outcome).
CONCLUSIONS:
OSA is associated with obesity and worse metabolic profiles in women with PCOS. However, whether the effects of OSA are independent of obesity remain unclear. As OSA is a treatable condition, research focused on the independent effects of OSA on key clinical outcomes in women with PCOS, including fertility, psychological health, type 2 diabetes and cardiovascular risk is lacking and needed.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Administration > Information and Digital Group > Library Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Population, Evidence & Technologies (PET) Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences > Translational & Experimental Medicine Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Polycystic ovary syndrome -- Patients, Sleep apnea syndromes, Metabolism -- Disorders, Systematic reviews (Medical research) | ||||||||
Journal or Publication Title: | Sleep | ||||||||
Publisher: | American Academy of Sleep Medicine | ||||||||
ISSN: | 1550-9109 | ||||||||
Official Date: | July 2018 | ||||||||
Dates: |
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Volume: | 41 | ||||||||
Number: | 7 | ||||||||
Article Number: | zsy085 | ||||||||
DOI: | 10.1093/sleep/zsy085 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Restricted or Subscription Access | ||||||||
Date of first compliant deposit: | 5 June 2018 | ||||||||
Date of first compliant Open Access: | 2 May 2019 |
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