Azharian, Sahar, Neal, Matthew, Kyrou, Iannos, Vrbikova, Jana, Hainer, Voitech, Sramkova, Petra, Fried, Martin, Piya, Milan K., Kumar, Sudhesh, Covington, James A. and McTernan, P. G. (Philip G.) (2016) LBPS 01-22 Volatile organic compounds : a potential biomarker for prediction of hypertension post-bariatric surgery. In: Society for Endocrinology BES 2016, Brighton, UK, 07-09 Nov 2016 . Published in: Journal of Hypertension, 34 (e-Supplement 1). doi:10.1097/01.hjh.0000500391.94644.e4 ISSN 0263-6352.

Research output not available from this repository.

Request-a-Copy directly from author or use local Library Get it For Me service.

Request Changes to record.

Abstract

Objective: Human obesity can significantly contribute to hypertension risk, often referred to as the “silent killer”, although targeting whom with weight gain becomes clinically hypertensive is unclear. Whilst therapeutic intervention such as bariatric surgery can mitigate both obesity and hypertension, it is not the most suitable solution for all patients. Therefore an early biomarker detection system to assess hypertension in subjects with weight gain could reduce mortality risk. Such a platform could be developed through a urine centred biomarker system identifying disease related signatures based upon volatile organic compounds (VOCs). The focus of this study was to determine whether urinary VOCs could be used as a potential monitoring tool for detection of blood pressure change in obese- hypertensive bariatric patients.

Design and Method: Pre-surgery urine of 23 obese female patients undergoing bariatric surgery was analysed by Field-Asymmetric Ion Mobility Spectrometer (FAIMS). The data was processed by dividing the cohort into two classifications (high and low) based on individual median values: systolic and diastolic blood pressure, mean arterial pressure (MAP), C-reactive protein (CRP) and heart rate. Support Vector Machine (SVM) classifiers were trained with features selected using the Wilcoxon rank sum test. Performance was assessed using 10-fold cross-validation and the area under the ROC curve (AUC).

Results: FAIMS urinary VOC analysis highlighted a significant association with blood pressure markers as determined by systolic (ROC curve AUC: 0.918, p < 0.001), MAP (AUC: 0.845 p < 0.001), CRP (AUC: 0.932, p < 0.001) and heart rate (AUC: 0.945, p < 0.001); whilst diastolic did not attain significance (AUC: 0., p = N.S). Additionally the VOCs have predicted change in blood pressure factors 6 months post surgery.

Conclusions: This study suggests that urinary VOCs can be used for monitoring change in blood pressure in bariatric patients, additionally this technique could be utilised as a novel-screening tool for prediction of hypertension risk in subjects.

Item Type:	Conference Item (Poster)
Divisions:	Faculty of Science, Engineering and Medicine > Engineering > Engineering Faculty of Science, Engineering and Medicine > Research Centres > Warwick Systems Biology Centre Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School
Journal or Publication Title:	Journal of Hypertension
Publisher:	Lippincott Williams & Wilkins, Ltd.
ISSN:	0263-6352
Official Date:	September 2016
Dates:	Date Event September 2016 Published
Volume:	34
Number:	e-Supplement 1
Article Number:	e180
DOI:	10.1097/01.hjh.0000500391.94644.e4
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access
Conference Paper Type:	Poster
Title of Event:	Society for Endocrinology BES 2016
Type of Event:	Conference
Location of Event:	Brighton, UK
Date(s) of Event:	07-09 Nov 2016

Request changes or add full text files to a record

Repository staff actions (login required)

View Item