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Cell polarity in yeast
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Chiou, Jian-geng, Balasubramanian, Mohan K. and Lew, Daniel J. (2017) Cell polarity in yeast. Annual Review of Cell and Developmental Biology, 33 (1). pp. 77-101. doi:10.1146/annurev-cellbio-100616-060856 ISSN 1081-0706.
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Official URL: http://dx.doi.org/10.1146/annurev-cellbio-100616-0...
Abstract
A conserved molecular machinery centered on the Cdc42 GTPase regulates cell polarity in diverse organisms. Here we review findings from budding and fission yeasts that reveal both a conserved core polarity circuit and several adaptations that each organism exploits to fulfill the needs of its lifestyle. The core circuit involves positive feedback by local activation of Cdc42 to generate a cluster of concentrated GTP-Cdc42 at the membrane. Species-specific pathways regulate the timing of polarization during the cell cycle, as well as the location and number of polarity sites.
| Item Type: | Journal Article | ||||||
|---|---|---|---|---|---|---|---|
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Biomedical Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Annual Review of Cell and Developmental Biology | ||||||
| Publisher: | Annual Reviews | ||||||
| ISSN: | 1081-0706 | ||||||
| Official Date: | October 2017 | ||||||
| Dates: |
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| Volume: | 33 | ||||||
| Number: | 1 | ||||||
| Page Range: | pp. 77-101 | ||||||
| DOI: | 10.1146/annurev-cellbio-100616-060856 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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