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Science forum : unit of analysis issues in laboratory-based research
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Parsons, Nicholas R., Teare, M. Dawn and Sitch, Alice J. (2018) Science forum : unit of analysis issues in laboratory-based research. eLife, 7 . e32486. doi:10.7554/eLife.32486 ISSN 2050-084X.
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Official URL: https://doi.org/10.7554/eLife.32486
Abstract
Many studies in the biomedical research literature report analyses that fail to recognise important data dependencies from multilevel or complex experimental designs. Statistical inferences resulting from such analyses are unlikely to be valid and are often potentially highly misleading. Failure to recognise this as a problem is often referred to in the statistical literature as a unit of analysis (UoA) issue. Here, by analysing two example datasets in a simulation study, we demonstrate the impact of UoA issues on study efficiency and estimation bias, and highlight where errors in analysis can occur. We also provide code (written in R) as a resource to help researchers undertake their own statistical analyses.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > R Medicine (General) | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Medicine -- Research -- Statistics -- Methodology | ||||||
Journal or Publication Title: | eLife | ||||||
Publisher: | eLife Sciences Publications Ltd. | ||||||
ISSN: | 2050-084X | ||||||
Official Date: | 10 January 2018 | ||||||
Dates: |
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Volume: | 7 | ||||||
Article Number: | e32486 | ||||||
DOI: | 10.7554/eLife.32486 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 14 June 2018 | ||||||
Date of first compliant Open Access: | 15 June 2018 |
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