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Data for Preparation and characterisation of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size
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Baker, Ysobel R., Chen, Jinfeng, Brown, Jason, El-Sagheer, Afaf H., Wiseman, Philip, Johnson, Errin, Goddard, Paul and Brown, Tom (2018) Data for Preparation and characterisation of manganese, cobalt and zinc DNA nanoflowers with tuneable morphology, DNA content and size. [Dataset]
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Archive (ZIP) (Zip archive)
Baker_et_al_dataarchive.zip - Published Version Available under License Creative Commons Attribution 4.0. Download (12Kb) |
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Plain Text (Readme file)
ReadMe.txt - Published Version Available under License Creative Commons Attribution 4.0. Download (854b) |
Abstract
Recently reported DNA nanoflowers are an interesting class of organic-inorganic hybrid materials which are prepared using DNA polymerases. DNA nanoflowers combine the high surface area and scaffolding of inorganic Mg2P2O7 nanocrystals with the targeting properties of DNA, whilst adding enzymatic stability and enhanced cellular uptake. We have investigated conditions for chemically modifying the inorganic core of these nanoflowers through substitution of Mg2+ with Mn2+, Co2+ or Zn2+ and have characterised the resulting particles. These have a range of novel nanoarchitectures, retain the enzymatic stability of their magnesium counterparts and the Co2+ and Mn2+ DNA nanoflowers have added magnetic properties. We investigate conditions to control different morphologies, DNA content, hybridisation properties, and size. Additionally, we show that DNA nanoflower production is not limited to Ф29 DNA polymerase and that the choice of polymerase can influence the DNA length within the constructs. We anticipate that the added control of structure, size and chemistry will enhance future applications.
| Item Type: | Dataset | |||||||||
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| Subjects: | Q Science > QP Physiology | |||||||||
| Divisions: | Faculty of Science > Physics | |||||||||
| Type of Data: | Experimental data | |||||||||
| Library of Congress Subject Headings (LCSH): | DNA polymerases, Nanocrystals, Nucleic acids | |||||||||
| Publisher: | Department of Physics | |||||||||
| Official Date: | 21 June 2018 | |||||||||
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| Status: | Not Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Media of Output: | .dat | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| Copyright Holders: | University of Warwick | |||||||||
| Description: | Data record consists of a zip archive containing the data files in .dat format and a readme file. Data files are named according to the corresponding figure in the related paper. |
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