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Mortality in relation to changes in a Healthy Aging Index : the health, aging, and body composition study

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O’Connell, Matthew, Marron, Megan M., Boudreau, Robert M., Canney, Mark, Sanders, Jason L., Kenny, Rose Anne, Kritchevsky, Stephen B., Harris, Tamara B. and Newman, Anne B. (2019) Mortality in relation to changes in a Healthy Aging Index : the health, aging, and body composition study. The Journals of Gerontology: Series A, 74 (5). pp. 726-732. doi:10.1093/gerona/gly114

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Official URL: https://doi.org/10.1093/gerona/gly114

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Abstract

Background
Baseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality.

Methods
Data are from the Health, Aging, and Body Composition study of well-functioning adults aged 70–79 years. A HAI, which ranges from 0 to 10, was constructed at years 1 and 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C, and fasting glucose. The relationships between the HAI at years 1 and 10 and the change between years and subsequent mortality until year 17 were estimated from Cox proportional hazards models.

Results
Two thousand two hundred sixty-four participants had complete data on a HAI at year 1, of these 1,122 had complete data at year 10. HAI scores tended to increase (i.e. get worse) over 9-year follow-up, from (mean [SD]) 4.3 (2.1) to 5.7 (2.1); mean within-person change 1.5 (1.6). After multivariable adjustment, HAI score was related to mortality from year 1 (hazard ratio [95% confidence interval] = 1.17 [1.13–1.21] per unit) and year 10 (1.20 [1.14–1.27] per unit). The change between years was also related to mortality (1.08 [1.02–1.15] per unit change).

Conclusions
HAI scores tended to increase with advancing age and stratified mortality rates among participants remaining at year 10. The HAI may prove useful to understand changes in health with aging.

Item Type: Journal Article
Subjects: R Medicine > RA Public aspects of medicine
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
SWORD Depositor: Library Publications Router
Library of Congress Subject Headings (LCSH): Life expectancy, Longevity, Older people -- Health and hygiene, Aging, Older people -- Mortality
Journal or Publication Title: The Journals of Gerontology: Series A
Publisher: Oxford University Press (OUP)
ISSN: 1758-535X
Official Date: May 2019
Dates:
DateEvent
May 2019Published
4 May 2018Available
17 April 2018Accepted
Volume: 74
Number: 5
Page Range: pp. 726-732
DOI: 10.1093/gerona/gly114
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
N01-AG-6-2101NHS England‏http://viaf.org/viaf/305940918
N01-AG-6-2103NHS England‏http://viaf.org/viaf/305940918
N01-AG-6-2106NHS England‏http://viaf.org/viaf/305940918
R01-AG-028050National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
R01-NR-012459National Institute of Nursing Researchhttp://dx.doi.org/10.13039/100000056
Ageing Research Leadership FellowshipCentre for Ageing Research and Development in Irelandhttp://dx.doi.org/10.13039/501100001582
Paul B Beeson Career Development Awards in Aging ResearchAmerican Federation for Aging Researchhttp://dx.doi.org/10.13039/100000965
P30 AG 21332Claude Pepper Older Americans Independence Center, Wake Forest School of Medicinehttp://dx.doi.org/10.13039/100008479
P30 AG024827Claude Pepper Older Americans Independence Center, University of PittsburghUNSPECIFIED
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