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Mortality in relation to changes in a Healthy Aging Index : the health, aging, and body composition study
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O’Connell, Matthew, Marron, Megan M., Boudreau, Robert M., Canney, Mark, Sanders, Jason L., Kenny, Rose Anne, Kritchevsky, Stephen B., Harris, Tamara B. and Newman, Anne B. (2018) Mortality in relation to changes in a Healthy Aging Index : the health, aging, and body composition study. The Journals of Gerontology: Series A . doi:10.1093/gerona/gly114 (In Press)
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Official URL: https://doi.org/10.1093/gerona/gly114
Abstract
Background
Baseline scores on a Healthy Aging Index (HAI), including five key physiologic domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality.
Methods
Data are from the Health, Aging, and Body Composition study of well-functioning adults aged 70–79 years. A HAI, which ranges from 0 to 10, was constructed at years 1 and 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C, and fasting glucose. The relationships between the HAI at years 1 and 10 and the change between years and subsequent mortality until year 17 were estimated from Cox proportional hazards models.
Results
Two thousand two hundred sixty-four participants had complete data on a HAI at year 1, of these 1,122 had complete data at year 10. HAI scores tended to increase (i.e. get worse) over 9-year follow-up, from (mean [SD]) 4.3 (2.1) to 5.7 (2.1); mean within-person change 1.5 (1.6). After multivariable adjustment, HAI score was related to mortality from year 1 (hazard ratio [95% confidence interval] = 1.17 [1.13–1.21] per unit) and year 10 (1.20 [1.14–1.27] per unit). The change between years was also related to mortality (1.08 [1.02–1.15] per unit change).
Conclusions
HAI scores tended to increase with advancing age and stratified mortality rates among participants remaining at year 10. The HAI may prove useful to understand changes in health with aging.
| Item Type: | Journal Article | ||||||||||||||||||||||||||||||
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| Subjects: | R Medicine > RA Public aspects of medicine | ||||||||||||||||||||||||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| SWORD Depositor: | Library Publications Router | ||||||||||||||||||||||||||||||
| Library of Congress Subject Headings (LCSH): | Life expectancy, Longevity, Older people -- Health and hygiene, Aging, Older people -- Mortality | ||||||||||||||||||||||||||||||
| Journal or Publication Title: | The Journals of Gerontology: Series A | ||||||||||||||||||||||||||||||
| Publisher: | Oxford University Press (OUP) | ||||||||||||||||||||||||||||||
| ISSN: | 1758-535X | ||||||||||||||||||||||||||||||
| Official Date: | 4 May 2018 | ||||||||||||||||||||||||||||||
| Dates: |
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| Date of first compliant deposit: | 18 July 2018 | ||||||||||||||||||||||||||||||
| DOI: | 10.1093/gerona/gly114 | ||||||||||||||||||||||||||||||
| Status: | Peer Reviewed | ||||||||||||||||||||||||||||||
| Publication Status: | In Press | ||||||||||||||||||||||||||||||
| Access rights to Published version: | Restricted or Subscription Access | ||||||||||||||||||||||||||||||
| RIOXX Funder/Project Grant: |
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