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Design and mechanism of action of novel organoiridium(iii) azopyridine anticancer complexes
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Hughes, George Marc (2018) Design and mechanism of action of novel organoiridium(iii) azopyridine anticancer complexes. PhD thesis, University of Warwick.
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Official URL: http://webcat.warwick.ac.uk/record=b3178959~S15
Abstract
This thesis is concerned with the synthesis, characterisation, and purification of 19 organoiridium(III) complexes, seventeen of which are novel. The complexes are of the general structure [CpX Ir(azopyridine)Z]A, where the iridium centre is coordinated to either a pentamethyl-cyclopentadienyl (Cp*) ligand, a tetramethyl(phenyl)-cyclopentadienyl Cpxph ligand, or a tetramethyl(biphenyl)-cyclopentadienyl Cpxbiph ligand. The azopyridine acts as an N,N-chelated bidentate ligand with a variety of substituents, the chemical and biological e↵ects of which are investigated. Z represents a monodentate halido ligand. In this work, complexes with chlorido and iodido ligands in this position are investigated. A represents the counterion to the cationic organoiridium complex. In this work, complexes bearing the hexafluorophosphate (PF6 ), Cl , and I anions are investigated. X-ray crystal structures of eight of the complexes are determined, confirming that the complexes adopt the expected ’piano-stool’ configuration. The anticancer properties of these complexes are thoroughly investigated in multiple cancer cell lines, revealing that several are more potent than many clinically-utilised chemotherapeutics including cisplatin (CDDP), as well as many previously reported metal-based anticancer complexes. The mechanism of action (MoA) of this family of complexes has been investigated, revealing an MoA based on the generation of reactive oxygen species (ROS) and superoxide (SO) in addition to mitochondrial membrane depolarisation. Drugs with this MoA hold the potential to selectively kill cancer cells over normal ones as cancer cells have higher levels of basal ROS and are therefore more sensitive to perturbation of their ROS balance. The charge, solubility, hydrophobicity, hydrolytic behaviour, and mechanism of action (MoA) of these complexes can all be modified with small synthetically trivial adjustments, resulting in highly potent complexes. This demonstrates this family of complexes as an effective and versatile platform for drug design.
Item Type: | Thesis (PhD) | ||||
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Subjects: | Q Science > QD Chemistry R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology |
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Library of Congress Subject Headings (LCSH): | Organoiridium compounds -- Synthesis, Organoiridium compounds -- Purification, Antineoplastic agents, Chemotherapy | ||||
Official Date: | January 2018 | ||||
Dates: |
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Institution: | University of Warwick | ||||
Theses Department: | Molecular Organisation and Assembly in Cells | ||||
Thesis Type: | PhD | ||||
Publication Status: | Unpublished | ||||
Supervisor(s)/Advisor: | Sadler, P. J. | ||||
Extent: | xvi, 313 pages : illustrations, charts | ||||
Language: | eng |
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