de Takats, P. G., Dunn, Janet A., Kerr, D. J. and Morrison, J. M. (1993) Impact of adjuvant chemotherapy in breast cancer on response to tamoxifen at relapse. Cancer Treatment Reviews, 19 (Supplement B). pp. 11-19. doi:10.1016/0305-7372(93)90003-A

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Abstract

A series of 105 patients with operable breast cancer previously entered in the WMOA adjuvant therapy trials were reviewed in order to assess methods of treatment on relapse and subsequent patterns of relapse and survival, related to previous adjuvant therapy. Tamoxifen was the predominant medical therapy offered on relapse. Unexpectedly, analysis of the relapse and survival data for these hormonetreated patients suggested that prior adjuvant therapy negatively influenced response to tamoxifen, with overall survival of treated and control patients being identical. Although not statistically significant, possible explanations of this trend have been explored.

Item Type:	Journal Article
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School
Journal or Publication Title:	Cancer Treatment Reviews
Publisher:	Elsevier BV
ISSN:	0305-7372
Official Date:	1 April 1993
Dates:	Date Event 1 April 1993 Published
Volume:	19
Number:	Supplement B
Page Range:	pp. 11-19
DOI:	10.1016/0305-7372(93)90003-A
Status:	Peer Reviewed
Publication Status:	Published
Access rights to Published version:	Restricted or Subscription Access

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