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Practicalities of using an adaptive design for decision making within the optima trial : optimal personalized treatment of early breast cancer using multi-parameter tests
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Dunn, Janet A., Marshall, A. (Andrea), Campbell, Amy, Cameron, D., Earl, H., Macpherson, I., Poole, C., Rea, D., Francis, A., Harmer, V., Morgan, A., Stallard, Nigel, Makris, A., Hughes-Davies, L. and Stein, R. (2015) Practicalities of using an adaptive design for decision making within the optima trial : optimal personalized treatment of early breast cancer using multi-parameter tests. Trials, 16 (Supplement 2). P212. doi:10.1186/1745-6215-16-S2-P212
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Official URL: https://doi.org/10.1186/1745-6215-16-S2-P212
Abstract
Multi-parameter gene expression assays (MPA) to aid selection of chemotherapy in hormone-sensitive early breast cancer have not been prospectively validated. This field of personalised medicine is rapidly evolving. There is currently no “best test”. OPTIMA is an adaptive trial of MPA-based chemotherapy assignment in a largely node-positive breast cancer population.
Item Type: | Journal Item | ||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Journal or Publication Title: | Trials | ||||
Publisher: | Biomed Central Ltd | ||||
ISSN: | 1745-6215 | ||||
Official Date: | 16 November 2015 | ||||
Dates: |
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Volume: | 16 | ||||
Number: | Supplement 2 | ||||
Article Number: | P212 | ||||
DOI: | 10.1186/1745-6215-16-S2-P212 | ||||
Status: | Peer Reviewed | ||||
Publication Status: | Published | ||||
Access rights to Published version: | Restricted or Subscription Access | ||||
Open Access Version: |
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