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Can we predict a high risk group in ovarian cancer?
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Finn, C. B., Dunn, Janet A., Buxton, E. J., Luesley, D. M. and Shafi, M. (1993) Can we predict a high risk group in ovarian cancer? International Journal of Gynecological Cancer, 3 (4). pp. 226-230. doi:10.1046/j.1525-1438.1993.03040226.x
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Official URL: https://doi.org/10.1046/j.1525-1438.1993.03040226....
Abstract
A retrospective review of 373 patients with stage I invasive epithelial ovarian cancer was undertaken over a 5 year period to develop a model to characterize the patient at high risk. Actuarial 5‐year survival was 70%. To identify factors with an independent effect on 5‐year survival, a logistic regression analysis was performed. Adjuvant chemotherapy, histologic grade and peritoneal washings, were identified as independent variables. A model to determine the predictivity of survival was created using a learning sample (2/3 of the cases) and the model was then used to reclassify a validation sample (1/3 of the cases). Using all the independent variables, outcome was predicted correctly in 78% of cases. However the model failed to improve identification of those at risk of recurrence (specificity of 53%).
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | International Journal of Gynecological Cancer | ||||||
| Publisher: | Lippincott Williams & Wilkins | ||||||
| ISSN: | 1048-891X | ||||||
| Official Date: | August 1993 | ||||||
| Dates: |
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| Volume: | 3 | ||||||
| Number: | 4 | ||||||
| Page Range: | pp. 226-230 | ||||||
| DOI: | 10.1046/j.1525-1438.1993.03040226.x | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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