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Can we predict a high risk group in ovarian cancer?

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Finn, C. B., Dunn, Janet A., Buxton, E. J., Luesley, D. M. and Shafi, M. (1993) Can we predict a high risk group in ovarian cancer? International Journal of Gynecological Cancer, 3 (4). pp. 226-230. doi:10.1046/j.1525-1438.1993.03040226.x

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Official URL: https://doi.org/10.1046/j.1525-1438.1993.03040226....

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Abstract

A retrospective review of 373 patients with stage I invasive epithelial ovarian cancer was undertaken over a 5 year period to develop a model to characterize the patient at high risk. Actuarial 5‐year survival was 70%. To identify factors with an independent effect on 5‐year survival, a logistic regression analysis was performed. Adjuvant chemotherapy, histologic grade and peritoneal washings, were identified as independent variables. A model to determine the predictivity of survival was created using a learning sample (2/3 of the cases) and the model was then used to reclassify a validation sample (1/3 of the cases). Using all the independent variables, outcome was predicted correctly in 78% of cases. However the model failed to improve identification of those at risk of recurrence (specificity of 53%).

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: International Journal of Gynecological Cancer
Publisher: Lippincott Williams & Wilkins
ISSN: 1048-891X
Official Date: August 1993
Dates:
DateEvent
August 1993Published
28 July 1992Accepted
Volume: 3
Number: 4
Page Range: pp. 226-230
DOI: 10.1046/j.1525-1438.1993.03040226.x
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

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