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Evaluation of pepsinogen a and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions
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Hallissey, M. T., Dunn, Janet A. and Fielding, J. W. L. (1994) Evaluation of pepsinogen a and gastrin-17 as markers of gastric cancer and high-risk pathologic conditions. Scandinavian Journal of Gastroenterology, 29 (12). pp. 1129-1134. doi:10.3109/00365529409094899
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Official URL: https://doi.org/10.3109/00365529409094899
Abstract
Background: Gastric cancer remains a major cause of mortality and will remain so for the lifetime of current clinicians. Many cancers are diagnosed at a stage when current therapy cannot provide the hope of cure. A method for early detection of gastric cancer which can be widely applied is needed. The serum levels of pepsinogen A and gastrin-17 have been shown to vary in the presence of pathologic conditions of the gastric mucosa and may provide such a tool.
Methods: Serum samples were obtained from 432 patients undergoing endoscopy for undiagnosed dyspepsia. The levels of pepsinogen I and gastrin-17 were estimated by radioimmunoassay and compared with the final diagnosis. Discriminant analysis was performed to assess the value of the the peptides predicting the presence of gastric cancer and the high-risk mucosal changes.
Results: Abnormal levels of gastrin-17 or pepsinogen A were found in 60% of patients with gastric cancer and 60% of those with one of the high-risk mucosal changes, the latter figure rising to 75% when the changes were in the upper third of the stomach. Discriminant analysis showed the log of gastrin-17 and log of pepsinogen A to be the best predictors of the high-risk mucosal changes, gastric cancer, and benign disease.
Conclusions: These results confirm gastrin-17 and pepsinogen A as markers of pathologic gastric conditions and suggest that these peptides are potential screening tools worthy of further assessment.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | Scandinavian Journal of Gastroenterology | ||||||
| Publisher: | Taylor & Francis | ||||||
| Official Date: | 1994 | ||||||
| Dates: |
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| Volume: | 29 | ||||||
| Number: | 12 | ||||||
| Page Range: | pp. 1129-1134 | ||||||
| DOI: | 10.3109/00365529409094899 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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