UNSPECIFIED. (2002) Iron and copper chelation by flavonoids: an electrospray mass spectrometry study. JOURNAL OF INORGANIC BIOCHEMISTRY, 92 (2). pp. 105-111. ISSN 0162-0134

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Abstract

Flavonoids are well known as effective free radical scavengers exhibiting therefore an antioxidant behaviour. Another antioxidant mechanism however may result from the ability they have to chelate metal ions, rendering them inactive to participate in free radical generating reactions. Electrospray. Mass spectrometry has been used to study metal ion interactions with a set of flavonoids from different classes. Complexes with a range of stoichiometries, of metal: flavonoid, 1:1, 1:2 -2:2, 2:3 have been observed. The stoichfometry 1:2 is in general the preferred one. It is established for flavones and for the flavanone naringenin that the binding metal sites Are preferentially at the 5-hydroxyl and 4-oxo, groups. Redox reactions are also observed through the change of the oxidation state of the metal, jointly with the oxidation of the flavonoid by loss of hydrogen. Structures of the oxidized species of some flavonoids are proposed. (C) 2002 Elsevier Science Inc. All rights reserved.

Item Type:	Journal Article
Subjects:	Q Science > QD Chemistry
Journal or Publication Title:	JOURNAL OF INORGANIC BIOCHEMISTRY
Publisher:	ELSEVIER SCIENCE INC
ISSN:	0162-0134
Date:	11 November 2002
Volume:	92
Number:	2
Number of Pages:	7
Page Range:	pp. 105-111
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/10412

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