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Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer
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Stonelake, P. S., Bundred, N. J., Neoptolemos, N. P., Baker, P. R., Baker, P. G., Gillespie, W. M., Dunn, Janet A., Spooner, D., Morrison, J. M., Bundred, N. J., Oates, G. D., Stonelake, P. S., Lee, M. J. R., Neoptolemos, J. P. and Chan, S. Y. (1994) Steroid receptors, pS2 and cathepsin D in early clinically node-negative breast cancer. European Journal of Cancer Care, 30 (1). pp. 5-11. doi:10.1016/S0959-8049(05)80008-5
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Official URL: https://doi.org/10.1016/S0959-8049(05)80008-5
Abstract
Four oestrogen-regulated proteins of reported prognostic value, oestrogen receptor (ER), progesterone receptor (PR), pS2 and cathepsin D (Cat D), have been quantified by immunoassays, and the latter studied by immunohistochemistry (IHC) in primary tumours from clinically node-negative early breast cancer patients, entered into a trial of breast conservation therapy in which all the patients received adjuvant tamoxifen. ER, PR and pS2 significantly co-correlated but none correlated with Cat D. ER, PR and pS2, but not Cat D, were significantly associated with tumour size and grade, although Cat D tended to show an inverse relationship with the latter. Cat D (radioimmunoassay) in pmol/mg significantly correlated with the IHC score for Cat D in carcinoma cells as well as the number of Cat D-expressing macrophages. At a median follow-up of only 16 months, recurrence was significantly more common in patients with tumours having negative status for ER, PR and pS2 but was not associated with Cat D status.
| Item Type: | Journal Article | ||||||
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| Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School |
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| Journal or Publication Title: | European Journal of Cancer Care | ||||||
| Publisher: | Wiley-Blackwell Publishing Ltd. | ||||||
| ISSN: | 0961-5423 | ||||||
| Official Date: | 1994 | ||||||
| Dates: |
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| Volume: | 30 | ||||||
| Number: | 1 | ||||||
| Page Range: | pp. 5-11 | ||||||
| DOI: | 10.1016/S0959-8049(05)80008-5 | ||||||
| Status: | Peer Reviewed | ||||||
| Publication Status: | Published | ||||||
| Access rights to Published version: | Restricted or Subscription Access |
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