Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

The selection of cases for randomised trials : a registry survey of concurrent trial and non-trial patients

Tools
- Tools
+ Tools

Ward, L. C., Fielding, J. W. L. and Dunn, Janet A. (1992) The selection of cases for randomised trials : a registry survey of concurrent trial and non-trial patients. British Journal of Cancer, 66 (5). pp. 943-950. doi:10.1038/bjc.1992.390

Research output not available from this repository, contact author.
Official URL: https://doi.org/10.1038/bjc.1992.390

Request Changes to record.

Abstract

A randomised trial of adjuvant chemotherapy vs placebo in operable stomach cancer recruited 249
patients from the West Midlands Region between 1976-1980. A Cancer Registry survey identified a further
1261 suitable concurrent cases. Trial patients were compared with the 960 non-trial cases from participating
Districts. Only 493 (51%) non-trial cases passed all of the prospective trial selection criteria for entry. Stage
and fitness caused the majority of exclusions and were also highly prognostic. A univariate analysis comparing eligible patients with the trial showed the two groups to be balanced for the
significant independent prognostic factors of the trial. However, differences in patient age and the surgery
performed indicate that recruitment may have been influenced by unknown selection factors. This survey
highlights the difficulty of retrospective selection and confirms the need for randomised controls. Data
available from specialist Registries may be used to help develop new protocols and to verify and extend trial
results.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences > Clinical Trials Unit
Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School
Journal or Publication Title: British Journal of Cancer
Publisher: Nature Publishing Group
ISSN: 0007-0920
Official Date: 1 November 1992
Dates:
DateEvent
1 November 1992Published
Volume: 66
Number: 5
Page Range: pp. 943-950
DOI: 10.1038/bjc.1992.390
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Restricted or Subscription Access

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us