UNSPECIFIED. (2002) Aggregate data meta-analysis with time-to-event outcomes. STATISTICS IN MEDICINE, 21 (22). pp. 3337-3351. ISSN 0277-6715

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Abstract

In a meta-analysis of randomized controlled trials with time-to-event outcomes, an aggregate data approach may be required for some or all included studies. Variation in the reporting of survival analyses in journals suggests that no single method for extracting the log(hazard ratio) estimate will suffice. Methods are described which improve upon a previously proposed method for estimating the log(HR) from survival curves. These methods extend to life-tables. In the situation where the treatment effect varies over time and the trials in the meta-analysis have different lengths of follow-up, heterogeneity may be evident. In order to assess whether the hazard ratio changes with time, several tests are proposed and compared. A cohort study comparing life expectancy of males and females with cerebral palsy and a systematic review of five trials comparing two anti-epileptic drugs, carbamazepine and sodium valproate, are used for illustration. Copyright (C) 2002 John Wiley Sons, Ltd.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine Q Science > QA Mathematics
Journal or Publication Title:	STATISTICS IN MEDICINE
Publisher:	JOHN WILEY & SONS LTD
ISSN:	0277-6715
Date:	30 November 2002
Volume:	21
Number:	22
Number of Pages:	15
Page Range:	pp. 3337-3351
Identification Number:	10.1002/sim.1303
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/10430

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