Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Antimicrobial drug use and infection control practices associated with the prevalence of methicillin-resistant Staphylococcus aureus in European hospitals

Tools
- Tools
+ Tools

MacKenzie, F.M., Bruce, J. (Julie), Struelens, M.J., Goossens, H., Mollison, J. and Gould, I.M. (2007) Antimicrobial drug use and infection control practices associated with the prevalence of methicillin-resistant Staphylococcus aureus in European hospitals. Clinical Microbiology and Infection, 13 (3). pp. 269-276. doi:10.1111/j.1469-0691.2006.01592.x ISSN 1198743X.

An open access version can be found in:
  • Publisher
Official URL: http://dx.doi.org/10.1111/j.1469-0691.2006.01592.x

Request Changes to record.

Abstract

Major regional variations in the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) are observed across Europe. This study investigated hospital MRSA prevalence in relation to patterns of antimicrobial use and infection control policies in an observational, cross-sectional study that used retrospective data from 2001 and linear regression to model relationships. MRSA prevalence (median 20.8%, n =173 hospitals) and antimicrobial consumption (median 55.2 defined daily doses/100 bed-days, n =140 hospitals) both varied significantly according to geographical region (p < 0.001). MRSA prevalence and antimicrobial consumption data were provided by 128 hospitals, and showed a strong statistical relationship between macrolide use and MRSA prevalence. Use of (i) third-generation cephalosporins, (ii) all antimicrobial agents, and (iii) all antimicrobial agents except glycopeptides was also associated with MRSA prevalence. Up to 146 hospitals provided data on MRSA prevalence and key infection control parameters. Adjusted linear regression modelling provided strong evidence that infection control policy recommendations associated with lower MRSA prevalence rates were (i) use of alcohol-based solutions for hand hygiene (mean difference 10.3%, 99%, CI1.2-10.3), and (ii) placement of MRSA patients in single rooms (mean difference 11.2%, 99% CI1.4-20.9). Hospitals with problems in implementing isolation policies had higher resistance levels (mean difference 12%, 99% CI3.8-20.1). Additional recommendations showed less evidence of association with a low MRSA prevalence. Overall, this study highlighted significant associations between MRSA prevalence, antimicrobial use and various key infection control parameters, all of which showed significant individual variations according to geographical region. © 2007 European Society of Clinical Microbiology and Infectious Diseases.

Item Type: Journal Article
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit
Journal or Publication Title: Clinical Microbiology and Infection
Publisher: Elsevier
ISSN: 1198743X
Official Date: March 2007
Dates:
DateEvent
2 August 2006Accepted
March 2007Published
Volume: 13
Number: 3
Page Range: pp. 269-276
DOI: 10.1111/j.1469-0691.2006.01592.x
Status: Peer Reviewed
Publication Status: Published
Grant number: QLK2-CT-2001-00915
Open Access Version:
  • Publisher

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item
twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us