UNSPECIFIED (2002) Xbra3 elicits the production of neural tissue by a non-BMP-dependent mechanism in Xenopus sp. MECHANISMS OF DEVELOPMENT, 118 (1-2). pp. 65-75. ISSN 0925-4773

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Abstract

Ectoderm cells in animal caps from Xenopus embryos develop to form either epidermis or neural tissue depending upon their receipt of intercellular signals. To date, several secreted neural inducers have been identified which act through the local inhibition of bone morphogenetic protein (BMP) signaling, preventing differentiation. to epidermis and resulting in adoption of neural fate. In this work, we have exploited an interspecies animal cap assay, which enables detection of the effects of signaling molecules produced by cells of one animal cap and influencing development in a second cap cultured in close apposition in a Hollfreter combination. We show that expression of the T-box protein, Xbra3, in one cap causes the production of a factor, which causes Adoption of neural fate by cells of the other animal cap. The action of this factor is not inhibited by the over-expression of BMP in cells of the responding animal cap, or by the inhibition of Wnt signaling. These findings suggest the existence of a secreted signaling molecule that is able to induce ectodermal cells to adopt neural fate by a mechanism independent of the inhibition of the BMP or Wnt signaling pathways. (C) 2002 Published by Elsevier Science Ireland Ltd.

Item Type:	Journal Article
Subjects:	Q Science > QH Natural history > QH301 Biology
Journal or Publication Title:	MECHANISMS OF DEVELOPMENT
Publisher:	ELSEVIER SCIENCE BV
ISSN:	0925-4773
Date:	October 2002
Volume:	118
Number:	1-2
Number of Pages:	11
Page Range:	pp. 65-75
Publication Status:	Published
URI:	http://wrap.warwick.ac.uk/id/eprint/10472

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