Skip to content Skip to navigation
University of Warwick
  • Study
  • |
  • Research
  • |
  • Business
  • |
  • Alumni
  • |
  • News
  • |
  • About

University of Warwick
Publications service & WRAP

Highlight your research

  • WRAP
    • Home
    • Search WRAP
    • Browse by Warwick Author
    • Browse WRAP by Year
    • Browse WRAP by Subject
    • Browse WRAP by Department
    • Browse WRAP by Funder
    • Browse Theses by Department
  • Publications Service
    • Home
    • Search Publications Service
    • Browse by Warwick Author
    • Browse Publications service by Year
    • Browse Publications service by Subject
    • Browse Publications service by Department
    • Browse Publications service by Funder
  • Help & Advice
University of Warwick

The Library

  • Login
  • Admin

Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium

Tools
- Tools
+ Tools

Lophatananon, Artitaya, Stewart-Brown, Sarah L., Kote-Jarai, Zsofia, Olama, Ali Amin Al, Garcia, Sara Benlloch, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Giles, Graham G, Fitzgerald, Liesel M et al.
(2017) Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium. British Journal of Cancer, 117 (5). pp. 734-743. doi:10.1038/bjc.2017.231

[img]
Preview
PDF
WRAP-height-selected-genetic-markers-prostate-cancer-risk-Stewart-Brown-2017.pdf - Published Version - Requires a PDF viewer.
Available under License Creative Commons Attribution 4.0.

Download (793Kb) | Preview
Official URL: http://dx.doi.org/10.1038/bjc.2017.231

Request Changes to record.

Abstract

Background:
Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.

Methods:
We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.

Results:
The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01–1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.

Conclusions:
There was no evidence of gene-environment interaction between height and the selected candidate SNPs.

Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.

Item Type: Journal Article
Subjects: R Medicine > RC Internal medicine
Divisions: Faculty of Medicine > Warwick Medical School > Health Sciences
Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology
Faculty of Medicine > Warwick Medical School
Library of Congress Subject Headings (LCSH): Prostate -- Cancer, Stature -- Health aspects, Nutrition, Prostate -- Cancer -- Prevention, Genetic markers
Journal or Publication Title: British Journal of Cancer
Publisher: Nature Publishing Group
ISSN: 0007-0920
Official Date: 22 August 2017
Dates:
DateEvent
22 August 2017Available
23 June 2017Accepted
Volume: 117
Number: 5
Page Range: pp. 734-743
DOI: 10.1038/bjc.2017.231
Status: Peer Reviewed
Publication Status: Published
Access rights to Published version: Open Access
RIOXX Funder/Project Grant:
Project/Grant IDRIOXX Funder NameFunder ID
HEALTH-F2-2009-223175FP7 Healthhttp://dx.doi.org/10.13039/100011272
C1287/A10118Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C1287/A10710Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C12292/A11174Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C1281/A12014Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C5047/A8384Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C5047/A15007Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C5047/A10692Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C8197/A16565Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
CA128978National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
1U19 CA148537National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
1U19 CA148065National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
1U19 CA148112National Institutes of Healthhttp://dx.doi.org/10.13039/100000002
W81XWH-10-1-0341U.S. Department of Defensehttp://dx.doi.org/10.13039/100000005
UNSPECIFIEDCanadian Institutes of Health Researchhttp://dx.doi.org/10.13039/501100000024
C18281/A19169Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C5047/A7357Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C5047/A3354Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
C16913/A6135Cancer Research UKhttp://dx.doi.org/10.13039/501100000289
Contributors:
ContributionNameContributor ID
Research GroupAPCB BioResource, UNSPECIFIED
Research GroupThe PRACTICAL consortium, UNSPECIFIED

Request changes or add full text files to a record

Repository staff actions (login required)

View Item View Item

Downloads

Downloads per month over past year

View more statistics

twitter

Email us: wrap@warwick.ac.uk
Contact Details
About Us