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Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium
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(2017) Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium. British Journal of Cancer, 117 (5). pp. 734-743. doi:10.1038/bjc.2017.231
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WRAP-height-selected-genetic-markers-prostate-cancer-risk-Stewart-Brown-2017.pdf - Published Version - Requires a PDF viewer. Available under License Creative Commons Attribution 4.0. Download (793Kb) | Preview |
Official URL: http://dx.doi.org/10.1038/bjc.2017.231
Abstract
Background:
Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.
Methods:
We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.
Results:
The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01–1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.
Conclusions:
There was no evidence of gene-environment interaction between height and the selected candidate SNPs.
Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.
| Item Type: | Journal Article | |||||||||
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| Subjects: | R Medicine > RC Internal medicine | |||||||||
| Divisions: | Faculty of Medicine > Warwick Medical School > Health Sciences Faculty of Medicine > Warwick Medical School > Health Sciences > Statistics and Epidemiology Faculty of Medicine > Warwick Medical School |
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| Library of Congress Subject Headings (LCSH): | Prostate -- Cancer, Stature -- Health aspects, Nutrition, Prostate -- Cancer -- Prevention, Genetic markers | |||||||||
| Journal or Publication Title: | British Journal of Cancer | |||||||||
| Publisher: | Nature Publishing Group | |||||||||
| ISSN: | 0007-0920 | |||||||||
| Official Date: | 22 August 2017 | |||||||||
| Dates: |
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| Date of first compliant deposit: | 16 July 2018 | |||||||||
| Volume: | 117 | |||||||||
| Number: | 5 | |||||||||
| Page Range: | pp. 734-743 | |||||||||
| DOI: | 10.1038/bjc.2017.231 | |||||||||
| Status: | Peer Reviewed | |||||||||
| Publication Status: | Published | |||||||||
| Access rights to Published version: | Open Access | |||||||||
| RIOXX Funder/Project Grant: | ||||||||||
| Contributors: |
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