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Diversity of astroglial effects on aging- and experience-related cortical metaplasticity
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Lalo, Ulyana, Bogdanov, Alexander and Pankratov, Yuriy (2018) Diversity of astroglial effects on aging- and experience-related cortical metaplasticity. Frontiers in Molecular Neuroscience, 11 . 239. doi:10.3389/fnmol.2018.00239 ISSN 1662-5099.
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Official URL: http://dx.doi.org/10.3389/fnmol.2018.00239
Abstract
Activity-dependent regulation of synaptic plasticity, or metaplasticity, plays a key role in the adaptation of neuronal networks to physiological and biochemical changes in aging brain. There is a growing evidence that experience-related alterations in the mechanisms of synaptic plasticity can underlie beneficial effects of physical exercise and caloric restriction (CR) on brain health and cognition. Astrocytes, which form neuro-vascular interface and can modulate synaptic plasticity by release of gliotransmitters, attract an increasing attention as important element of brain metaplasticity. We investigated the age- and experience-related alterations in astroglial calcium signaling and stimulus-dependence of long-term synaptic plasticity in the neocortex of mice exposed to the mild CR and environmental enrichment (EE) which included ad libitum physical exercise. We found out that astrocytic Ca2+-signaling underwent considerable age-related decline but EE and CR enhanced astroglial signaling, in particular mediated by noradrenaline (NA) and endocannabinoid receptors. The release of ATP and D-Serine from astrocytes followed the same trends of age-related declined and EE-induced increase. Our data also showed that astrocyte-derived ATP and D-Serine can have diverse effects on the threshold and magnitude of long-term changes in the strength of neocortical synapses; these effects were age-dependent. The CR- and EE-induced enhancement of astroglial Ca2+-signaling had more stronger effect on synaptic plasticity in the old (14–18 months) than in the young (2–5 months) wild-type (WT) mice. The effects of CR and EE on synaptic plasticity were significantly altered in both young and aged dnSNARE mice. Combined, our data suggest astrocyte-neuron interactions are important for dynamic regulation of cortical synaptic plasticity. This interaction can significantly decline with aging and thus contributes to the age-related cognitive impairment. On another hand, experience-related increase in the astroglial Ca2+-signaling can ameliorate the age-related decline.
Item Type: | Journal Article | ||||||
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Subjects: | R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry | ||||||
Divisions: | Faculty of Science, Engineering and Medicine > Science > Life Sciences (2010- ) | ||||||
Library of Congress Subject Headings (LCSH): | Neurosciences -- Molecular aspects, Neuroplasticity, Brain -- Aging | ||||||
Journal or Publication Title: | Frontiers in Molecular Neuroscience | ||||||
Publisher: | Frontiers Research Foundation | ||||||
ISSN: | 1662-5099 | ||||||
Official Date: | 13 July 2018 | ||||||
Dates: |
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Volume: | 11 | ||||||
Article Number: | 239 | ||||||
DOI: | 10.3389/fnmol.2018.00239 | ||||||
Status: | Peer Reviewed | ||||||
Publication Status: | Published | ||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||
Date of first compliant deposit: | 17 July 2018 | ||||||
Date of first compliant Open Access: | 17 July 2018 | ||||||
RIOXX Funder/Project Grant: |
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