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Indirect and mixed treatment comparisons in arthritis research
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Ades, A. E., Madan, Jason and Welton, N. J. (2011) Indirect and mixed treatment comparisons in arthritis research. Rheumatology, 50 (Supplement 4). iv5- iv9. doi:10.1093/rheumatology/ker241
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Official URL: https://doi.org/10.1093/rheumatology/ker241
Abstract
Evidence for the efficacy of biologic therapies in inflammatory arthritis comes overwhelmingly from placebo-controlled trials. Increasingly, however, authorities responsible for purchasing and re-imbursement have tried to determine whether there are differences between these powerful new therapies, which would lead them to recommend some in preference to others, either on grounds of efficacy or costeffectiveness. In the absence of head-to-head trial comparisons, indirect comparisons may be used. Furthermore, network meta-analysis, also known as mixed treatment comparisons can combine information from trials in a connected network. These methods allow inferences about head-to-head comparisons even when there is little or no head-to-head evidence, which has caused some concern. In this article we briefly review these methodologies and describe results from recent applications to inflammatory arthritis in the clinical literature. We then focus on how the methodologies are used in decision making, taking as an illustration some recent technology appraisals conducted by the National Institute for Health and Clinical Excellence in the UK. We conclude that, in practice, the key decisions have been based on results from placebo-controlled trials. © The Author 2011. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | R Medicine > R Medicine (General) | ||||
| Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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| Journal or Publication Title: | Rheumatology | ||||
| Publisher: | Oxford University Press | ||||
| ISSN: | 1462-0324 | ||||
| Official Date: | 2 February 2011 | ||||
| Dates: |
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| Volume: | 50 | ||||
| Number: | Supplement 4 | ||||
| Page Range: | iv5- iv9 | ||||
| DOI: | 10.1093/rheumatology/ker241 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published | ||||
| Access rights to Published version: | Restricted or Subscription Access | ||||
| Funder: | Arthritis Research UK |
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