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Protein design depends on the size of the amino acid alphabet
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Ball, Robin and Fink, Thomas M. A. (2002) Protein design depends on the size of the amino acid alphabet. Physical Review E (Statistical, Nonlinear, and Soft Matter Physics), Vol.66 (No.3, Pt.1). Article 031902 . doi:10.1103/PhysRevE.66.031902
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Official URL: http://dx.doi.org/10.1103/PhysRevE.66.031902
Abstract
We consider the design of proteins to be simultaneously thermodynamically stable in multiple independent and correlated conformations. We first show that a protein can be trained to fold to multiple independent conformations and calculate its capacity. The number of configurations that it can remember is proportional to the logarithm of the number of amino acid species A, independent of chain length. Next we investigate the recognition of correlated conformations, which we apply to funnel design around a single configuration. The maximum basin of attraction, as parametrized in our model, also depends on the number of amino acid species as ln A. We argue that the extent to which the protein energy landscape can be manipulated is fixed, effecting a trade off between well breadth, well depth, and well number. This emerging picture motivates a clearer understanding of the scope and limits of protein and heteropolymer function.
| Item Type: | Journal Article | ||||
|---|---|---|---|---|---|
| Subjects: | Q Science > QC Physics T Technology > TP Chemical technology |
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| Divisions: | Faculty of Science, Engineering and Medicine > Science > Physics | ||||
| Library of Congress Subject Headings (LCSH): | Protein engineering, Amino acids | ||||
| Journal or Publication Title: | Physical Review E (Statistical, Nonlinear, and Soft Matter Physics) | ||||
| Publisher: | American Physical Society | ||||
| ISSN: | 1550-2376 | ||||
| Official Date: | September 2002 | ||||
| Dates: |
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| Volume: | Vol.66 | ||||
| Number: | No.3, Pt.1 | ||||
| Number of Pages: | 7 | ||||
| Page Range: | Article 031902 | ||||
| DOI: | 10.1103/PhysRevE.66.031902 | ||||
| Status: | Peer Reviewed | ||||
| Publication Status: | Published |
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