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Body mass index and breast cancer survival : a Mendelian randomization analysis
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(2017) Body mass index and breast cancer survival : a Mendelian randomization analysis. International Journal of Epidemiology, 46 (6). pp. 1814-1822. doi:10.1093/ije/dyx131 ISSN 0300-5771.
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Official URL: http://dx.doi.org/10.1093/ije/dyx131
Abstract
Background
There is increasing evidence that elevated body mass index (BMI) is associated with reduced survival for women with breast cancer. However, the underlying reasons remain unclear. We conducted a Mendelian randomization analysis to investigate a possible causal role of BMI in survival from breast cancer.
Methods
We used individual-level data from six large breast cancer case-cohorts including a total of 36 210 individuals (2475 events) of European ancestry. We created a BMI genetic risk score (GRS) based on genotypes at 94 known BMI-associated genetic variants. Association between the BMI genetic score and breast cancer survival was analysed by Cox regression for each study separately. Study-specific hazard ratios were pooled using fixed-effect meta-analysis.
Results
BMI genetic score was found to be associated with reduced breast cancer-specific survival for estrogen receptor (ER)-positive cases [hazard ratio (HR)=1.11, per one-unit increment of GRS, 95% confidence interval (CI) 1.01-1.22, P=0.03). We observed no association for ER-negative cases (HR=1.00, per one-unit increment of GRS, 95% CI 0.89-1.13, P=0.95).
Conclusions
Our findings suggest a causal effect of increased BMI on reduced breast cancer survival for ER-positive breast cancer. There is no evidence of a causal effect of higher BMI on survival for ER-negative breast cancer cases.
Item Type: | Journal Article | ||||||||
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Subjects: | R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) | ||||||||
Divisions: | Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Clinical Trials Unit Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School > Health Sciences Faculty of Science, Engineering and Medicine > Medicine > Warwick Medical School |
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Library of Congress Subject Headings (LCSH): | Breast -- Cancer, Body mass index | ||||||||
Journal or Publication Title: | International Journal of Epidemiology | ||||||||
Publisher: | Oxford University Press | ||||||||
ISSN: | 0300-5771 | ||||||||
Official Date: | 1 December 2017 | ||||||||
Dates: |
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Volume: | 46 | ||||||||
Number: | 6 | ||||||||
Page Range: | pp. 1814-1822 | ||||||||
DOI: | 10.1093/ije/dyx131 | ||||||||
Status: | Peer Reviewed | ||||||||
Publication Status: | Published | ||||||||
Access rights to Published version: | Open Access (Creative Commons) | ||||||||
Date of first compliant deposit: | 21 February 2019 | ||||||||
Date of first compliant Open Access: | 21 February 2019 |
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